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首页> 外文期刊>The British journal of psychiatry : >Rumination-focused cognitive-behavioural therapy for residual depression: phase II randomised controlled trial
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Rumination-focused cognitive-behavioural therapy for residual depression: phase II randomised controlled trial

机译：以反刍为重点的认知行为疗法治疗残留抑郁症：II期随机对照试验

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摘要

Background About 20% of major depressive episodes become chronic and medication-refractory and also appear to be less responsive to standard cognitive-behavioural therapy (CBT). Aims To test whether CBT developed from behavioural activation principles that explicitly and exclusively targets depressive rumination enhances treatment as usual (TAU) in reducing residual depression. Method Forty-two consecutively recruited participants meeting criteria for medication-refractory residual depression were randomly allocated to TAU v. TAU plus up to 12 sessions of individual rumination-focused CBT. The trial has been registered (ISRCTN22782150). Results Adding rumination-focused CBT to TAU significantly improved residual symptoms and remission rates. Treatment effects were mediated by change in rumination. Conclusions This is the first randomised controlled trial providing evidence of benefits of rumination-focused CBT in persistent depression. Although suggesting the internal validity of rumination-focused CBT for residual depression, the trial lacked an attentional control group so cannot test whether the effects were as a result of the specific content of rumination-focused CBT v. non-specific therapy effects. Declaration of interest None.
机译：背景技术大约20％的主要抑郁症发作会变成慢性和难治性药物，并且对标准的认知行为疗法（CBT）的反应似乎也较弱。目的测试CBT是否从明确且专门针对抑郁性反刍的行为激活原理发展而来，能够像往常一样（TAU）来减少残留的抑郁症。方法将符合药物难治性残余抑郁标准的42位连续入选的参与者随机分配至TAU诉TAU，外加多达12场针对反刍的CBT。该试验已注册（ISRCTN22782150）。结果在TAU中添加针对反刍的CBT可以显着改善残留症状和缓解率。通过反刍作用的改变来介导治疗效果。结论这是第一项随机对照试验，提供了以反刍为主的CBT对持续抑郁的益处的证据。尽管表明了反刍集中CBT对残留抑郁症的内部有效性，但该试验缺乏注意对照组，因此无法测试其效果是否是针对反刍集中CBT诉非特异性治疗作用的具体结果。利益声明无。

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