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首页> 外文期刊>The British journal of psychiatry : >Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder
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Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder

机译：注意缺陷多动障碍患者亲属的双相情感障碍和精神分裂症风险

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Background: Attention-deficit hyperactivity disorder (ADHD) is associated with bipolar disorder and schizophrenia, and it has been suggested that combined bipolar disorder and ADHD is aetiologically distinct from the pure disorders. Aims: To clarify whether ADHD shares genetic and environmental factors with bipolar disorder and schizophrenia. Method: By linking longitudinal Swedish national registers, we identified 61 187 persons with ADHD (the proband group) and their first- and second-degree relatives, and matched them with a control group of people without ADHD and their corresponding relatives. Conditional logistic regression was used to determine the risks of bipolar disorder and schizophrenia in the relatives of the two groups. Results: First-degree relatives of the ADHD proband group were at increased risk of both bipolar disorder (odds ratio (OR) = 1.84-2.54 for parents, offspring and full siblings) and schizophrenia (OR = 1.71-2.22 for parents, offspring and full siblings). The risks of bipolar disorder and schizophrenia among second-degree relatives were substantially lower than among full siblings. Conclusions: These findings suggest that the co-occurrence of ADHD and bipolar disorder as well as ADHD and schizophrenia is due to shared genetic factors, rather than representing completely aetiologically distinct subsyndromes.
机译：背景：注意缺陷多动障碍（ADHD）与躁郁症和精神分裂症有关，并且有人提出，躁郁症和ADHD的合并症在病因学上与单纯性病症不同。目的：阐明多动症是否与躁郁症和精神分裂症有共同的遗传和环境因素。方法：通过链接纵向瑞典国家登记簿，我们确定了61 187名患有ADHD的人（先证者组）及其一级和二级亲属，并将他们与没有ADHD的对照组及其相应的亲属相匹配。使用条件逻辑回归分析确定两组亲属的双相情感障碍和精神分裂症的风险。结果：ADHD先证者组的一级亲属患双相情感障碍（父母，后代和全兄弟姐妹的比值比（OR）= 1.84-2.54）和精神分裂症（父母，后代和其他人的OR = 1.71-2.22）的风险均增加。完整的兄弟姐妹）。二级亲属患双相情感障碍和精神分裂症的风险大大低于全兄弟姐妹。结论：这些发现表明，多动症和双相情感障碍以及多动症和精神分裂症的共同发生是由于共有的遗传因素，而不是代表完全的病因学上不同的亚综合征。

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