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首页> 外文期刊>The British journal of psychiatry : >Obstetric complications and risk of schizophrenia. Effect of gender, age at diagnosis and maternal history of psychosis.
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Obstetric complications and risk of schizophrenia. Effect of gender, age at diagnosis and maternal history of psychosis.

机译：产科并发症和精神分裂症的风险。性别，年龄对诊断和精神病史的影响。

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BACKGROUND: Obstetric complications have been studied frequently as possible risk factors for schizophrenia. AIMS: To test the hypotheses that individual obstetric complications are most strongly associated with an increased risk of schizophrenia in males, in patients with an early age at first diagnosis and in subjects with a maternal history of psychosis. METHOD: Cases of schizophrenia diagnosed between January 1971 and June 1994 were identified in the Stockholm County In-Patient Register. Controls were matched on age, gender, hospital of birth and parish of birth. Obstetric data were recorded blind to case-control status for 524 cases and 1043 controls. RESULTS: This study did not find any large or consistent effect of gender, age at diagnosis or maternal history of psychosis on the risk of schizophrenia associated with individual complications. CONCLUSIONS: Future studies should examine these effects using a much larger sample that includes patients with schizophrenia and control subjects whose genetic risk of schizophrenia has been assessed accurately.
机译：背景：产科并发症已作为精神分裂症的可能危险因素而被频繁研究。目的：为了检验以下假设：男性，首次诊断的早年患者和患有精神病史的受试者中，个别产科并发症与精神分裂症风险增加最密切相关。方法：在斯德哥尔摩县患者登记簿中确定了1971年1月至1994年6月之间诊断为精神分裂症的病例。对照在年龄，性别，出生医院和教区中匹配。记录了524例病例和1043例对照的盲目病例控制状态的产科数据。结果：本研究未发现性别，诊断时的年龄或精神病的母性史对与个体并发症相关的精神分裂症风险有任何大的或一致的影响。结论：未来的研究应使用更大的样本来检查这些影响，包括精神分裂症患者和控制对象，他们的精神分裂症遗传风险已得到准确评估。

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