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首页> 外文期刊>Chest: The Journal of Circulation, Respiration and Related Systems >Excessive daytime sleepiness and obstructive sleep apnea in patients with sarcoidosis
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Excessive daytime sleepiness and obstructive sleep apnea in patients with sarcoidosis

机译：结节病患者白天过度嗜睡和阻塞性睡眠呼吸暂停

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Background: Systemic symptoms are common in sarcoidosis and are associated with a decreased quality of life. Excessive daytime sleepiness (EDS) often is associated with obstructive sleep apnea (OSA) but may be a systemic symptom independently associated with sarcoidosis. The aim of this study was to assess the relationship between sarcoidosis and EDS. Methods: In a retrospective analysis, we used Epworth Sleepiness Scale scores to compare sleepiness in 62 patients with sarcoidosis with 1,005 adults without sarcoidosis referred for polysomnography for suspicion of OSA. Linear regression models controlled for covariates. In a subgroup analysis of patients with sarcoidosis, sleepiness scores and polysomnograms were compared between those with normal and those with abnormal pulmonary function based on total lung capacity. Results: EDS was more common in patients with sarcoidosis than in those without, and sarcoidosis remained an independent predictor of increased sleepiness after controlling for covariates. Compared with control patients referred for polysomnography, fewer patients with sarcoidosis had clinically significant OSA. However, among patients with sarcoidosis, OSA was more severe in those with abnormal lung function. Conclusions: Sarcoidosis is independently associated with EDS. Sleepiness may contribute to the morbidity of sarcoidosis and should be followed even after treating for potentially coexisting OSA or depression. Abnormal lung function in sarcoidosis may contribute to OSA, although the mechanisms for this are not known.
机译：背景：结节病常见于全身症状，并且与生活质量下降有关。白天过度嗜睡（EDS）通常与阻塞性睡眠呼吸暂停（OSA）有关，但可能是与结节病独立相关的全身症状。这项研究的目的是评估结节病和EDS之间的关系。方法：在一项回顾性分析中，我们使用Epworth嗜睡量表评分比较了62例结节病患者和1,005名无结节病的成年人的嗜睡情况，这些患者因多导睡眠图检查而怀疑OSA。控制协变量的线性回归模型。在结节病患者的亚组分析中，根据总肺活量比较了肺功能正常和异常的患者的嗜睡评分和多导睡眠图。结果：结节病患者中的EDS比没有结节病的患者更为普遍，结节病在控制协变量后仍是嗜睡增加的独立预测因子。与接受多导睡眠监测的对照患者相比，结节病患者具有显着的OSA的患者更少。但是，在结节病患者中，肺功能异常者的OSA更为严重。结论：结节病与EDS独立相关。嗜睡可能会导致结节病的发病，因此即使在治疗可能并存的OSA或抑郁症后也应注意。结节病的肺功能异常可能是OSA的原因，尽管其机制尚不清楚。

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