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首页> 外文期刊>Chest: The Journal of Circulation, Respiration and Related Systems >The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay, and after hospital discharge: a long-term follow-up study.
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The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay, and after hospital discharge: a long-term follow-up study.

机译：重症疾病对ICU治疗，住院和出院后与健康相关的生活质量的影响：一项长期随访研究。

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BACKGROUND: The time course of changes in health-related quality of life (HRQOL) following discharge from the ICU and during a general ward stay has not been studied. We therefore studied the immediate impact of critical illness on HRQOL and its recovery over time. METHODS: In a prospective study, all patients admitted to the ICU for > 48 h who ultimately survived to follow-up at 6 months were included. The Medical Outcomes Study 36-item short form was used to measure HRQOL before ICU admission, at discharge from the ICU and hospital, and at 3 and 6 months following discharge from the ICU and hospital. An age-matched healthy Dutch population was used as a reference. RESULTS: Of the 451 included patients, 252 could be evaluated at 6 months (40 were lost to follow-up, and 159 died). Pre-ICU admission HRQOL in survivors was significantly worse compared to the healthy population. Patients who died between ICU admission and long-term follow-up had significantly worse HRQOL in all dimensions already at ICU admission when compared to the long-term survivors. HRQOL decreased in all dimensions (p < 0.001) during ICU stay followed by a rapid improvement during hospital stay, gradually improving to near pre-ICU admission HRQOL at 6 months following ICU discharge. Physical functioning (PF), general health (GH), and social functioning (SF) remained significantly lower than pre-ICU admission values. Compared to the healthy Dutch population, ICU survivors had significantly lower HRQOL 6 months following ICU discharge (except for the bodily pain score). CONCLUSIONS: A sharp multidimensional decline in HRQOL occurs during ICU admission where recovery already starts following ICU discharge to the general ward. Recovery is incomplete for PF, GH, and SF when compared to baseline values and the healthy population.
机译：背景：从ICU出院后以及在普通病房期间，健康相关生活质量（HRQOL）随时间变化的过程尚未进行研究。因此，我们研究了严重疾病对HRQOL的直接影响及其随着时间的恢复。方法：在一项前瞻性研究中，纳入了所有在ICU住院> 48 h并最终在6个月后存活下来的患者。使用医学结果研究（Medical Outcomes Study）的36项简短形式来测量入ICU之前，ICU和医院出院时以及ICU和医院出院后3个月和6个月时的HRQOL。使用年龄匹配的健康荷兰人口作为参考。结果：在451例患者中，有252例在6个月时得到评估（40例失访，159例死亡）。与健康人群相比，ICU入院前幸存者的HRQOL明显较差。与长期幸存者相比，在ICU入院和长期随访之间死亡的患者在ICU入院时所有维度的HRQOL均显着恶化。在ICU住院期间HRQOL在所有方面均下降（p <0.001），随后在住院期间迅速改善，在ICU出院后6个月逐渐提高至接近ICU入院时HRQOL。身体机能（PF），总体健康（GH）和社会机能（SF）仍显着低于ICU之前的入院率。与健康的荷兰人相比，ICU出院后6个月，ICU幸存者的HRQOL明显降低（除了身体疼痛评分）。结论：ICU入院期间HRQOL发生了急剧的多维下降，其中ICU出院后已开始恢复。与基线值和健康人群相比，PF，GH和SF的恢复不完全。

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