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首页> 外文期刊>The European Journal of Neuroscience >Neural correlates of conflict resolution between automatic and volitional actions by basal ganglia.
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Neural correlates of conflict resolution between automatic and volitional actions by basal ganglia.

机译：基底神经节自动和自愿行动之间的冲突解决神经相关。

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A dominant basal ganglia (BG) model consists of two functionally opposite pathways: one facilitates motor output and the other suppresses it. Although this idea was originally proposed to account for motor deficits, it has been extended recently also to explain cognitive deficits. Here, we employed the antisaccade paradigm (look away from a stimulus) to address the role of the caudate nucleus, the main BG input stage where the two pathways diverge, in conflict resolution. Using single neuron recordings in awake monkeys, we identified the following three groups of neurons. The first group of neurons showed activity consistent with sensory-driven (automatic) saccades toward a contralateral visual stimulus. The second group of neurons showed activity consistent with internally driven (volitional) saccades toward the contralateral side regardless of stimulus locations. The third group of neurons showed similar firing characteristics with the second group of neurons, except that their preferred saccade direction was ipsilateral. The activity of the three groups of neurons was correlated with behavioral outcome. Based on these findings, we suggest the following hypothesis: the first and second groups of neurons encoding automatic and volitional saccades, respectively, might give rise to the facilitation (direct) pathway and promote saccades toward the opposite directions, which creates a response conflict. This conflict could be resolved by the third group of caudate neurons, which might give rise to the suppression (indirect) pathway and attenuate inappropriate saccade commands toward the stimulus.
机译：优势基底神经节（BG）模型由两条功能相反的途径组成：一种促进运动输出，另一种抑制运动输出。尽管最初提出该想法是为了解决运动功能障碍，但最近它也被扩展以解释认知功能障碍。在这里，我们采用了反扫视范式（远离刺激）来解决尾状核的作用，尾状核是冲突解决中两条途径分叉的主要BG输入阶段。使用清醒猴子中的单个神经元录音，我们确定了以下三组神经元。第一组神经元显示出与对侧视觉刺激的感觉驱动（自动）扫视一致的活动。无论刺激位置如何，第二组神经元的活动均与对侧的内部驱动（自愿）扫视一致。第三组神经元表现出与第二组神经元相似的放电特性，除了它们优选的扫视方向是同侧。三组神经元的活动与行为结果相关。基于这些发现，我们提出以下假设：分别编码自动扫视和自动扫视的第一和第二组神经元可能会产生促进（直接）途径，并朝着相反的方向推动扫视，从而造成反应冲突。这种冲突可以通过第三组尾状神经元解决，这可能会引起抑制（间接）途径，并减弱对刺激的不适当的扫视命令。

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