...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >The second brain and Parkinson's disease.
【24h】

The second brain and Parkinson's disease.

机译：第二脑和帕金森氏病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It has been classically considered that the pathological hallmarks of Parkinson's disease, namely Lewy bodies and Lewy neurites, affect primarily the substantia nigra. Nevertheless, it has become increasingly evident in recent years that Parkinson's disease is a multicentric neurodegenerative process that affects several neuronal structures outside the substantia nigra, among which is the enteric nervous system. Remarkably, recent reports have shown that the lesions in the enteric nervous system occurred at a very early stage of the disease, even before the involvement of the central nervous system. This led to the postulate that the enteric nervous system could be critical in the pathophysiology of Parkinson's disease, as it could represent a route of entry for a putative environmental factor to initiate the pathological process (Braak's hypothesis). Besides their putative role in the spreading of the pathological process, it has also been suggested that the pathological alterations within the enteric nervous system could be involved in the gastrointestinal dysfunction frequently encountered by parkinsonian patients. The scope of the present article is to review the available studies on the enteric nervous system in Parkinson's disease patients and in animal models of the disease. We further discuss the strategies that will help in our understanding of the roles of the enteric nervous system, both in the pathophysiology of the disease and in the pathophysiology of the gastrointestinal symptoms.
机译：帕金森氏病是仅次于阿尔茨海默氏病的第二大最常见的神经退行性疾病。传统上认为帕金森氏病的病理标志，即路易小体和路易神经突主要影响黑质。然而，近年来越来越明显的是帕金森氏病是多中心神经变性过程，其影响黑质以外的几个神经元结构，其中包括肠神经系统。值得注意的是，最近的报道表明，肠神经系统的病变发生在疾病的非常早期，甚至在中枢神经系统受累之前。这导致假定肠神经系统在帕金森氏病的病理生理学中可能至关重要，因为它可能代表假定的环境因素启动病理过程的进入途径（Braak假说）。除了在病理过程的传播中可能发挥的作用外，还提示肠神经系统内的病理改变可能与帕金森氏病患者经常遇到的胃肠功能障碍有关。本文的范围是审查有关帕金森氏病患者和该疾病的动物模型中肠神经系统的可用研究。我们将进一步讨论可帮助我们理解肠道神经系统在疾病的病理生理学和胃肠道症状的病理生理学中的作用的策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号