...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Inter-hemispheric inhibition is impaired in mirror dystonia.
【24h】

Inter-hemispheric inhibition is impaired in mirror dystonia.

机译：半球间抑制在镜像肌张力障碍中受损。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Surround inhibition, a neural mechanism relevant for skilled motor behavior, has been shown to be deficient in the affected primary motor cortex (M1) in patients with focal hand dystonia (FHD). Even in unilateral FHD, however, electrophysiological and neuroimaging studies have provided evidence for bilateral M1 abnormalities. Clinically, the presence of mirror dystonia, dystonic posturing when the opposite hand is moved, also suggests abnormal interhemispheric interaction. To assess whether a loss of inter-hemispheric inhibition (IHI) may contribute to the reduced surround inhibition, IHI towards the affected or dominant M1 was examined in 13 patients with FHD (seven patients with and six patients without mirror dystonia, all affected on the right hand) and 12 right-handed, age-matched healthy controls (CON group). IHI was tested at rest and during three different phases of a right index finger movement in a synergistic, as well as in a neighboring, relaxed muscle. There was a trend for a selective loss of IHI between the homologous surrounding muscles in the phase 50 ms before electromyogram onset in patients with FHD. Post hoc analysis revealed that this effect was due to a loss of IHI in the patients with FHD with mirror dystonia, while patients without mirror dystonia did not show any difference in IHI modulation compared with healthy controls. We conclude that mirror dystonia may be due to impaired IHI towards neighboring muscles before movement onset. However, IHI does not seem to play a major role in the general pathophysiology of FHD.
机译：周围抑制是一种与熟练的运动行为有关的神经机制，已被证明在局灶性手张力障碍（FHD）患者的受影响的原发性运动皮层（M1）中缺乏。但是，即使在单侧FHD中，电生理和神经影像学研究也为双侧M1异常提供了证据。在临床上，镜面肌张力障碍的存在，当另一只手移动时肌张力异常，也提示半球间相互作用异常。为了评估半球间抑制（IHI）的丧失是否可能导致周围抑制的降低，对13例FHD患者（7例有6例无镜张力障碍的患者，均受到影响）检查了IHI对受影响或显性M1的影响。右手）和12位年龄相匹配的右手健康对照者（CON组）。在休息时以及在右手食指运动的三个不同阶段（在协同作用下以及在相邻的松弛肌肉中）对IHI进行了测试。 FHD患者在肌电图发作前50 ms阶段，周围同源肌肉之间有选择性IHI丢失的趋势。事后分析显示，这种作用是由于患有镜反射性肌张力障碍的FHD患者的IHI丧失，而没有镜反射性肌张力障碍的患者与健康对照组相比，其IHI调节没有任何差异。我们得出结论，镜子肌张力障碍可能是由于运动开始前对邻近肌肉的IHI受损。但是，IHI在FHD的一般病理生理学中似乎没有发挥主要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号