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首页> 外文期刊>The European Journal of Neuroscience >Dopamine-oxytocin interactions in penile erection.
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Dopamine-oxytocin interactions in penile erection.

机译：多巴胺-催产素在阴茎勃起中的相互作用。

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Dopamine and oxytocin have established roles in the central regulation of penile erection in rats; however, the neural circuitries involved in a specific erectile context and the interaction between dopamine and oxytocin mechanisms remain to be elucidated. The medial preoptic area (MPOA), supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus may serve as candidate sites because they contain oxytocin cells, receive dopaminergic inputs and have been implicated in mediating masculine sexual behavior. Double immunofluorescence revealed that substantial numbers of oxytocin cells in the MPOA, SON and PVN possess dopamine D(2), D(3) and D(4) receptors. In anaesthetized rats, using intracavernous pressure as a physiological indicator of erection, blockade of lumbosacral oxytocin receptors (UK, 427843) reduced erectile responses to a nonselective dopamine agonist (apomorphine), suggesting that dopamine recruits a paraventriculospinal oxytocin pathway. In conscious males in the absence of a female, penile erection elicited by a D(2)/D(3) (Quinelorane) but not D(4) (PD168077) agonist was associated with activation of medial parvocellular PVN oxytocin cells. In another experiment where males were given full access to a receptive female, a D(4) (L-745870) but not D(2) or D(3) antagonist (L-741626; nafadotride) inhibited penile erection (intromission), and this was correlated with SON magnocellular oxytocin neuron activation. Together, the data suggest dopamine's effects on hypothalamic oxytocin cells during penile erection are context-specific. Dopamine may act via different parvocellular and magnocellular oxytocin subpopulations to elicit erectile responses, depending upon whether intromission is performed. This study demonstrates the potential existence of interaction between central dopamine and oxytocin pathways during penile erection, with the SON and PVN serving as integrative sites.
机译：多巴胺和催产素已在大鼠阴茎勃起的中央调节中发挥作用。然而，涉及特定勃起环境的神经回路以及多巴胺与催产素机制之间的相互作用仍有待阐明。下丘脑的视前内侧区域（MPOA），视上核（SON）和脑室旁核（PVN）可以充当候选位点，因为它们包含催产素细胞，接受多巴胺能输入并且与介导男性性行为有关。双重免疫荧光显示，MPOA，SON和PVN中的大量催产素细胞具有多巴胺D（2），D（3）和D（4）受体。在麻醉的大鼠中，使用海绵体内压力作为勃起的生理指标，阻断腰oxy催产素受体（英国，427843）可降低对非选择性多巴胺激动剂（阿扑吗啡）的勃起反应，这表明多巴胺募集了脑室旁脊髓催产素途径。在没有雌性的有意识的雄性中，由D（2）/ D（3）（喹啉烷）而非D（4）（PD168077）激动剂引起的阴茎勃起与内侧小细胞PVN催产素细胞的激活有关。在另一项允许男性完全接触女性的实验中，D（4）（L-745870）而非D（2）或D（3）拮抗剂（L-741626;那法多利）抑制了阴茎勃起（引言），这与SON大细胞催产素神经元活化有关。总之，数据表明在阴茎勃起期间多巴胺对下丘脑催产素细胞的作用是特定于环境的。多巴胺可能通过不同的小细胞和大细胞催产素亚群起作用，以引起勃起反应，这取决于是否进行了引流。这项研究表明在阴茎勃起过程中中央多巴胺和催产素途径之间可能存在相互作用，而SON和PVN则是整合位点。

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