...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Effects of stimulus-response compatibility on inhibitory processes in Parkinson's disease.
【24h】

Effects of stimulus-response compatibility on inhibitory processes in Parkinson's disease.

机译：刺激-反应相容性对帕金森氏病抑制过程的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Parkinson's disease (PD) is a neurodegenerative basal ganglia disorder accompanied by deficits in cognitive functions. One important executive function is the inhibition of responses. Due to basal ganglia damage, processes related to the selection of response are also dysfunctional. However, the relevance of deficits in response selection to processes related to response inhibition in PD is not clear. In this study we examined these processes by means of event-related potentials (ERPs) in two Go/Nogo tasks. In one task the stimulus-response mapping was compatible and in the other task it was incompatible with the meaning of the stimuli. The behavioural results show that PD patients were unaffected in the compatible response inhibition task but encountered problems in the incompatible one. In the ERPs the N2, generally reflecting response selection, was delayed for the PD compared to the control group. This suggests that response selection is delayed in PD. Moreover, the N2 was specifically enhanced in Nogo trials. This indicates that premotor inhibition, which is probably reflected by the Nogo-N2, is intensified in PD. The P3 was specifically attenuated and delayed after Nogo stimuli in the incompatible condition for PDs. Assuming that the Nogo-P3 reflects the evaluation of successful motor inhibition, our data show that this process is attenuated and delayed in PD but mainly in the incompatible task. The results suggest that inhibitory deficits in PD are only evident in complex (incompatible) stimulus-response mappings. These effects are probably due to an overstrain of striatal processes.
机译：帕金森氏病（PD）是一种神经退行性基底神经节疾病，伴有认知功能缺陷。一种重要的执行功能是抑制反应。由于基底神经节损伤，与反应选择有关的过程也不能正常工作。然而，尚不清楚反应选择中的缺陷与PD中与反应抑制相关的过程的相关性。在这项研究中，我们通过两个Go / Nogo任务中的事件相关电位（ERP）研究了这些过程。在一个任务中，刺激-反应映射是兼容的，而在另一任务中，它与刺激的含义不兼容。行为结果表明，PD患者在兼容反应抑制任务中未受影响，但在不兼容反应抑制任务中遇到了问题。在ERP中，与对照组相比，PD一般延迟了反映反应选择的N2。这表明响应选择在PD中被延迟。此外，N2在Nogo试验中得到了特别增强。这表明PD中可能会增强Nogo-N2的运动前抑制作用。在PD的不相容条件下，Nogo刺激后P3特异地减弱和延迟。假设Nogo-P3反映了成功的运动抑制评估，我们的数据表明该过程在PD中被减弱和延迟，但主要发生在不兼容的任务中。结果表明，PD的抑制缺陷仅在复杂的（不相容的）刺激反应图谱中明显。这些影响可能是由于纹状体过程过度紧张所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号