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首页> 外文期刊>The European Journal of Neuroscience >Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal network.
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Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal network.

机译：唤醒与昼夜节律行为之间的关系：腹膜下丘脑：饥饿-唤醒网络中的一个结点。

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摘要

The mechanisms by which animals adapt to an ever-changing environment have long fascinated scientists. Different forces, conveying information regarding various aspects of the internal and external environment, interact with each other to modulate behavioral arousal. These forces can act in concert or, at times, in opposite directions. These signals eventually converge and are integrated to influence a common arousal pathway which, depending on all the information received from the environment, supports the activation of the most appropriate behavioral response. In this review we propose that the ventromedial hypothalamic nucleus (VMN) is part of the circuitry that controls food anticipation. It is the first nucleus activated when there is a change in the time of food availability, silencing of VMN ghrelin receptors decreases food-anticipatory activity (FAA) and, although lesions of the VMN do not abolish FAA, parts of the response are often altered. In proposing this model it is not our intention to exclude parallel, redundant and possibly interacting pathways that may ultimately communicate with, or work in concert with, the proposed network, but rather to describe the neuroanatomical requirements for this circuit and to illustrate how the VMN is strategically placed and connected to mediate this complex behavioral adaptation.
机译：长期以来，科学家们对动物适应不断变化的环境的机制感兴趣。传递有关内部和外部环境各个方面的信息的不同力量相互影响，以调节行为唤醒。这些力量可以协同行动，有时甚至是相反的方向。这些信号最终会收敛并整合在一起，以影响一条共同的唤醒途径，这取决于从环境中接收到的所有信息，支持激活最适当的行为响应。在这篇综述中，我们提出腹侧下丘脑核（VMN）是控制食物预期的电路的一部分。当食物供应时间发生变化时，它是第一个激活的核，VMN ghrelin受体的沉默会降低食物预期活性（FAA），尽管VMN的病变不会消除FAA，但部分反应通常会改变。在提出此模型时，我们无意排除可能最终与提议的网络通信或协同工作的并行，冗余且可能相互作用的路径，而是描述该电路的神经解剖学要求并说明VMN被战略性地放置和连接以调解这种复杂的行为适应。

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