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首页> 外文期刊>The European Journal of Neuroscience >c-Fos expression in preoptic nuclei as a marker of sleep rebound in the rat.
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c-Fos expression in preoptic nuclei as a marker of sleep rebound in the rat.

机译：c-Fos在视前核中的表达作为大鼠睡眠反弹的标志。

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摘要

Thermoregulation is known to interfere with sleep, possibly due to a functional interaction at the level of the preoptic area (POA). Exposure to low ambient temperature (T(a)) induces sleep deprivation, which is followed by sleep rebound after a return to laboratory T(a). As two POA subregions, the ventrolateral preoptic nucleus (VLPO) and the median preoptic nucleus (MnPO), have been proposed to have a role in sleep-related processes, the expression of c-Fos and the phosphorylated form of the cAMP/Ca(2+)-responsive element-binding protein (P-CREB) was investigated in these nuclei during prolonged exposure to a T(a) of -10 degrees C and in the early phase of the recovery period. Moreover, the dynamics of the sleep rebound during recovery were studied in a separate group of animals. The results show that c-Fos expression increased in both the VLPO and the MnPO during cold exposure, but not in a specific subregion within the VLPO cluster counting grid (VLPO T-cluster). During the recovery, concomitantly with a large rapid eye movement sleep (REMS) rebound and an increase in delta power during non-rapid eye movement sleep (NREMS), c-Fos expression was high in both the VLPO and the MnPO and, specifically, in the VLPO T-cluster. In both nuclei, P-CREB expression showed spontaneous variations in basal conditions. During cold exposure, an increase in expression was observed in the MnPO, but not in the VLPO, and a decrease was observed in both nuclei during recovery. Dissociation in the changes observed between c-Fos expression and P-CREB levels, which were apparently subject to state-related non-regulatory modulation, suggests that the sleep-related changes observed in c-Fos expression do not depend on a P-CREB-mediated pathway.
机译：已知体温调节会干扰睡眠，这可能是由于在视前区（POA）层面发生了功能性相互作用。暴露于低环境温度（T（a））会导致睡眠不足，然后返回实验室T（a）后出现睡眠反弹。作为两个POA子区域，腹侧前视神经核（VLPO）和中视前视神经核（MnPO）已被提出在睡眠相关过程，c-Fos的表达和cAMP / Ca（在长时间暴露于-10摄氏度的T（a）期间和恢复期的早期，研究了这些细胞核中的2+）反应性元素结合蛋白（P-CREB）。此外，在另一组动物中研究了恢复期间睡眠反弹的动力学。结果表明，c-Fos表达在冷暴露期间在VLPO和MnPO中均增加，但在VLPO群集计数网格（VLPO T群集）内的特定子区域中没有增加。在恢复过程中，伴随着快速眼动睡眠（REMS）的大量反弹以及非快速眼动睡眠（NREMS）期间δ功率的增加，VLPO和MnPO的c-Fos表达均很高，特别是在VLPO T群集中。在两个核中，P-CREB的表达均显示出基础条件的自发变化。在冷暴露期间，在MnPO中观察到表达增加，但在VLPO中观察不到，并且在恢复过程中两个核均观察到表达减少。在c-Fos表达和P-CREB水平之间观察到的变化的解离，显然受到状态相关的非调节性调节，这表明c-Fos表达中观察到的与睡眠有关的变化不依赖于P-CREB介导的途径。

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