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首页> 外文期刊>The European Journal of Neuroscience >Tonic GABAergic control of mouse dentate granule cells during postnatal development.
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Tonic GABAergic control of mouse dentate granule cells during postnatal development.

机译：产后发育过程中对小鼠齿状颗粒细胞的补品GABA能控制。

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摘要

The dentate gyrus is the main hippocampal input structure receiving strong excitatory cortical afferents via the perforant path. Therefore, inhibition at this 'hippocampal gate' is important, particularly during postnatal development, when the hippocampal network is prone to seizures. The present study describes the development of tonic GABAergic inhibition in mouse dentate gyrus. A prominent tonic GABAergic component was already present at early postnatal stages (postnatal day 3), in contrast to the slowly developing phasic postsynaptic GABAergic currents. Tonic currents were mediated by GABA(A) receptors containing alpha(5)- and delta-subunits, which are sensitive to low ambient GABA concentrations. The extracellular GABA level was determined by synaptic GABA release and GABA uptake via the GABA transporter 1. The contribution of these main regulatory components was surprisingly stable during postnatal granule cell maturation. Throughout postnatal development, tonic GABAergic signals were inhibitory. They increased the action potential threshold of granule cells and reduced network excitability, starting as early as postnatal day 3. Thus, tonic inhibition is already functional at early developmental stages and plays a key role in regulating the excitation/inhibition balance of both the adult and the maturing dentate gyrus.
机译：齿状回是主要的海马输入结构，通过穿孔路径接收强的兴奋性皮质传入神经。因此，抑制这种“海马门”很重要，特别是在产后发育过程中，当海马网络容易发作时。本研究描述了小鼠齿状回中的强直GABA抑制作用的发展。与缓慢发展的阶段性突触后GABA能电流相反，在产后早期（产后第3天）已经出现了一个重要的补品GABA能成分。进补电流由含有对低环境GABA浓度敏感的alpha（5）-和delta-亚基的GABA（A）受体介导。细胞外GABA水平由突触GABA释放和通过GABA转运蛋白1摄取GABA决定。这些主要调控成分的作用在出生后的颗粒细胞成熟过程中出奇地稳定。在整个产后发育过程中，滋补GABA能信号均具有抑制作用。从出生后第3天开始，它们就增加了颗粒细胞的动作电位阈值并降低了网络兴奋性。因此，进补抑制作用已经在发育的早期阶段发挥了作用，并且在调节成年和成年小鼠的兴奋/抑制平衡中起着关键作用。成熟的齿状回。

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