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首页> 外文期刊>The European Journal of Neuroscience >Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro.
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Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro.

机译：α-2去甲肾上腺素能受体的激活对于在体外哺乳动物中产生虚构的气喘和虚构的喘气吸气活动至关重要。

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Biogenic amines are not just 'modulators', they are often essential for the execution of behaviors. Here, we explored the role of biogenic amines acting on the pre-Botzinger complex (pre-BotC), an area located in the ventrolateral medulla which is critical for the generation of different forms of breathing. Isolated in transverse slices from mice, this region continues to spontaneously generate rhythmic activities that resemble normal (eupneic) inspiratory activity in normoxia and gasping in hypoxia. We refer to these as 'fictive eupneic' and 'fictive gasping' activity. When exposed to hypoxia, the pre-BotC transitions from a network state relying on calcium-activated nonspecific cation currents (I(CAN)) and persistent sodium currents (I(Nap)) to one that primarily depends on the I(Nap) current. Here we show that in inspiratory neurons I(Nap)-dependent bursting, blocked by riluzole, but not I(CAN) -dependent bursting, required endogenously released norepinephrine acting on alpha2-noradrenergic receptors (alpha2-NR). At the network level, fictive eupneic activity persisted while fictive gasping ceased following the blockade of alpha2-NR. Blockade of alpha2-NR eliminated fictive gasping even in slice preparations as well as in inspiratory island preparations. Blockade of fictive gasping by alpha2-NR antagonists was prevented by activation of 5-hydroxytryptamine type 2A receptors (5-HT2A). Our data suggest that gasping depends on the converging aminergic activation of 5-HT2AR and alpha2-NR acting on riluzole-sensitive mechanisms that have been shown to be crucial for gasping.
机译：生物胺不仅是“调节剂”，它们通常对于执行行为也是必不可少的。在这里，我们探讨了生物胺作用于前Botzinger复合体（pre-BotC）的作用，前复合体位于腹侧延髓，对产生不同形式的呼吸至关重要。从小鼠的横切片中分离出来，该区域继续自发产生节律性活动，类似于正常氧（正常的吸气）吸气活动和缺氧时的喘息。我们称这些为“虚构的本性”和“虚构的喘气”活动。当暴露于缺氧状态时，pre-BotC从依赖钙激活的非特异性阳离子电流（I（CAN））和持续钠电流（I（Nap））的网络状态转变为主要依赖于I（Nap）电流的网络状态。在这里，我们显示在吸气神经元中，I（Nap）依赖性爆发被riluzole阻断，但I（CAN）依赖性爆发则不需要内源性释放释放的去甲肾上腺素，其作用于α2-去甲肾上腺素能受体（alpha2-NR）。在网络一级，假想的委婉活动持续存在，而假想的喘气在α2-NR阻滞后停止。甚至在切片制剂以及吸气岛制剂中，α2-NR的阻滞消除了虚假的喘气。通过激活2-羟基5-羟色胺2A受体（5-HT2A）防止了α2-NR拮抗剂对虚假喘息的阻断。我们的数据表明，喘气取决于5-HT2AR和α2-NR的共同胺能活化，作用于对利鲁唑敏感的机制，这对喘气至关重要。

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