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首页> 外文期刊>The European Journal of Neuroscience >Types and synaptic connections of hippocampal inhibitory neurons reciprocally connected with the medial septum.
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Types and synaptic connections of hippocampal inhibitory neurons reciprocally connected with the medial septum.

机译：海马抑制神经元的类型和突触连接与内侧间隔相互连接。

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摘要

The morphological properties and connectivity of gamma-aminobutyric acid (GABA)ergic hippocampal cells projecting to the medial septum (HS cells) were examined in the rat. Two types of HS cells are located in different layers of the hippocampus: sparsely-spiny cells are in CA1-3 str. oriens and CA3 str. radiatum, where recurrent axons of pyramidal cells arborize. Densely-spiny HS cells with spiny somata are located in the termination zone of granule cell axons. In the hilus, intermediate morphologies can also be found. HS cells receive GABAergic medial septal afferents in all layers where they occur, thus the connectivity of the septum and the hippocampus is reciprocal at cell level. HS cells receive extremely dense innervation, sparsely-spiny cells are innervated by approximately 19,000 excitatory inputs, while densely-spiny cells get an even larger number (approximately 37,000). While 14% of the inputs are inhibitory for the sparsely-spiny cells, it is only 2.3% in the case of densely-spiny cells. Because a high proportion (up to 54.5% on somata and 27.5% on dendrites) of their GABAergic inputs derived from labelled septal terminals, their predominant inhibitory input probably arises from the medial septum. CA1 area HS cells possessed myelinated projecting axons, as well as local collaterals, which targeted mostly pyramidal cell dendrites and spines in str. oriens and radiatum. The synaptic organization suggests that by sampling the activity of large populations of principal cells HS cells can reliably broadcast hippocampal activity level to the medial septum.
机译：在大鼠中检查了投射到内侧隔的伽马氨基丁酸（GABA）能海马细胞的形态学特性和连通性。两种类型的HS细胞位于海马的不同层：稀疏棘细胞位于CA1-3 str中。 Oriens和CA3 str。放射状，锥体细胞的复发轴突在其中。带有多刺躯体的密集多刺HS细胞位于颗粒细胞轴突的终止区。在hilus中，也可以找到中间形态。 HS细胞在其发生的所有层中均接受GABA能级中隔传入，因此在细胞水平上，中隔与海马的连通性是相互的。 HS细胞接受极为密集的神经支配，稀疏棘状细胞受约19,000个兴奋性输入的神经支配，而密集棘状细胞获得的数量甚至更多（约37,000）。尽管有14％的输入对稀疏棘细胞具有抑制作用，但在密集多刺细胞中只有2.3％。由于来自标记的中隔末端的GABA能输入中有很大比例（在躯体上高达54.5％，在树突上高达27.5％），因此其主要的抑制性输入可能来自内侧中隔。 CA1区HS细胞具有髓鞘突出的轴突，以及局部侧支，主要针对str中的锥体细胞树突和棘。 Oriens和半径。突触组织表明，通过对大量原代细胞的活性进行采样，HS细胞可以可靠地将海马活性水平传播至内侧隔。

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