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首页> 外文期刊>The European Journal of Neuroscience >Neonatal stimulation of 5-HT(2) receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area.
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Neonatal stimulation of 5-HT(2) receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area.

机译：新生儿刺激5-HT（2）受体减少大鼠前房室周围核和性二态性视前区中雄激素受体的表达。

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摘要

Masculinization of the brain is dependent upon a perinatal surge in testosterone. It also requires a transient decrease in hypothalamic 5-HT concentration and turnover and an increase in androgen receptor (AR) expression during the second postnatal week. We have previously shown that increasing 5-HT activity over this period in male or androgenized female rats feminizes their adult behaviour and also feminizes the size of their anteroventral periventricular nucleus (AVPV) and sexually dimorphic nucleus of the preoptic area (SDN-POA). To investigate the role of 5-HT in sexual differentiation of the brain, 5-HT activity was raised over postnatal days 8-16 in male, female and androgenized female rats by daily administration of the 5-HT(2) receptor agonist (-)[2,5 dimethoxy-4-iodophenyl]-2-amino propane hydrochloride [(-)DOI]. By postnatal day 18, the size of the AVPV and SDN-POA was sexually dimorphic; their sizes were feminized by (-)DOI treatment. In the absence of (-)DOI treatment, there were significantly more AR-immunoreactive cells in the AVPV of males, and in the SDN-POA of males and androgenized females, than in those of females on postnatal day 18. (-)DOI treatment reduced the number of AR-immunoreactive cells in the AVPV and SDN-POA of males and androgenized females, but not of females, by postnatal day 18. These results suggest that 5-HT(2) receptor activation can influence sexual differentiation of the brain by controlling AR expression.
机译：大脑的男性化取决于围产期睾丸激素的激增。在产后第二周，下丘脑5-HT浓度和周转率暂时降低，雄激素受体（AR）表达增加。先前我们已经表明，在此期间雄性或雄激素雌性大鼠中增加的5-HT活性女性化了其成年行为，并且女性化了其前腹膜前室周围核（AVPV）和视前区性二形核（SDN-POA）的大小。为了研究5-HT在大脑性别分化中的作用，通过每天服用5-HT（2）受体激动剂（- ）[2,5二甲氧基-4-碘苯基] -2-氨基丙烷盐酸盐[（-）DOI]。到出生后第18天，AVPV和SDN-POA的大小发生了两性分化;通过（-）DOI处理将其尺寸女性化。在没有（-）DOI治疗的情况下，男性的AVPV以及男性和雄激素化女性的SDN-POA中的AR免疫反应性细胞明显多于出生后第18天的女性。治疗减少了出生后第18天男性和雄激素化女性的AVPV和SDN-POA中AR免疫反应细胞的数量，但女性没有减少。这些结果表明，5-HT（2）受体激活可以影响性腺的性别分化。通过控制AR表达来控制大脑。

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