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首页> 外文期刊>The European Journal of Neuroscience >Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum.
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Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum.

机译:皮质和纹状体来源的神经干细胞在嗅球和纹状体中产生不同的后代。

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Neural stem cells can be isolated from the mouse embryonic cortex but do not persist in the adult cortex. In contrast, neural stem cells from the striatal embryonic germinal zone persist in the adult subependyma. Emx1-lineage analysis revealed that cortex-derived neural stem cells survive and migrate ventrally into the subependyma where they intermix with the host striatal neural stem cells [S. Willaime-Morawek et al. (2006)J. Cell Biol. 175, 159-168]. Cortex-derived cells proliferate faster in the subependyma and reach the olfactory bulb earlier than striatum-derived cells. In the olfactory bulb, cortex-derived cells produce more cells and more dopaminergic neurons in the glomerular layer than striatum-derived cells. Cortex-derived cells also give rise to more astrocytes and less neurons in the striatum than striatum-derived cells. Thus, history matters; cortex-derived neural stem cells in the subependyma give rise to progeny in the olfactory bulb and striatum but in different proportions than striatum-derived neural stem cells.
机译:可以从小鼠胚胎皮质中分离出神经干细胞,但在成年皮质中不存在。相反,来自纹状体胚胎生发区的神经干细胞仍存在于成人室管膜下。 Emx1谱系分析显示,皮层来源的神经干细胞存活并在腹侧迁移到室管膜下层,在那里它们与宿主纹状体神经干细胞混合[S. Willaime-Morawek等。 (2006)J.细胞生物学。 175,159-168]。皮层来源的细胞在室管膜下增殖更快,比纹状体来源的细胞更早到达嗅球。在嗅球中,与纹状体来源的细胞相比,皮质来源的细胞在肾小球层产生更多的细胞和更多的多巴胺能神经元。皮层来源的细胞也比纹状体来源的细胞产生更多的星形胶质细胞和较少的神经元。因此,历史很重要。室管膜下皮层来源的神经干细胞在嗅球和纹状体中产生子代,但比例不同于纹状体来源的神经干细胞。

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