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首页> 外文期刊>The European Journal of Neuroscience >The natriuretic effect of oxytocin blocks medial tuberomammillary polydipsia and polyuria in male rats.
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The natriuretic effect of oxytocin blocks medial tuberomammillary polydipsia and polyuria in male rats.

机译：催产素的利尿钠作用可阻断雄性大鼠的内侧结节性乳头性多饮和多尿。

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摘要

Lesions of the tuberomammillary complex, a neuroanatomical system closely related to the hypothalamic supraoptic and paraventricular nuclei, induce strong polydipsia in male rats. It was recently demonstrated that this increase in water intake is immediate, persistent, follows circadian rhythms and appears to be related to sodium regulation. The present study found that urine osmolality was significantly lower in tuberomammillary-lesioned animals vs. their respective controls at 8:00 h after surgery. Therefore, the aim of the present study was to examine the natriuretic effect of intraperitoneal oxytocin (OT) administration on medial ventral tuberomammillary nucleus (E3) polydipsia and polyuria of lesioned and control male rats. At 24:00 h post-lesion, OT blocked the hyperdipsic and polyuric responses of E3-lesioned animals but not those of non-lesioned controls, which did however significantly increase their water intake. Moreover, urinary osmolality and sodium excretion increased in E3 -lesioned animals that received OT but not in lesioned controls receiving physiological saline (992 +/- 187.19 vs. 215.83 +/- 23.39 mOsm/kg; 1.68 +/- 0.13 vs. 0.47 +/- 0.1 mEq/L). At 48:00 h post-lesion, OT administration also induced a higher intake of water and of simultaneously offered hypertonic NaCl (1.5%) in E3-lesioned animals. These results are interpreted in terms of the hypothalamic systems involved in sodium and water homeostasis.
机译：与下丘脑上视和脑室旁核密切相关的神经解剖系统-肺结核复合体病变在雄性大鼠中引起强烈的多视。最近证明，这种摄水量的增加是即时的，持续的，遵循昼夜节律的，并且似乎与钠的调节有关。本研究发现，在手术后8:00 h，患结核瘤的动物的尿渗透压明显低于其相应的对照组。因此，本研究的目的是检查腹膜内注射催产素（OT）对病变和对照雄性大鼠的内侧腹侧瘤胃乳核（E3）多饮和多尿的利钠作用。病变后24：00，OT阻断了E3病变动物的高双歧和多尿症反应，但未阻断非病变对照组的动物，但确实增加了它们的饮水量。此外，接受OT的E3病变动物的尿渗透压和钠排泄增加，但接受生理盐水的病变对照组却没有（992 +/- 187.19 vs.215.83 +/- 23.39 mOsm / kg; 1.68 +/- 0.13 vs. 0.47 + /-0.1 mEq / L）。病变后48：00，OT给药还导致E3病变动物的水摄入量增加，同时提供高渗NaCl（1.5％）。这些结果以涉及钠和水稳态的下丘脑系统来解释。

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