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首页> 外文期刊>The European Journal of Neuroscience >Circadian rhythms of PERIOD1 expression in the dorsomedial hypothalamic nucleus in the absence of entrained food-anticipatory activity rhythms in rats.
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Circadian rhythms of PERIOD1 expression in the dorsomedial hypothalamic nucleus in the absence of entrained food-anticipatory activity rhythms in rats.

机译：在没有夹带的食物预期活动性节律的大鼠中，PERIOD1在背体下丘脑核中的昼夜节律。

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摘要

When food availability is restricted to a single time of day, circadian rhythms of behavior and physiology in rodents shift to anticipate the predictable time of food arrival. It has been hypothesized that certain food-anticipatory rhythms are linked to the induction and entrainment of rhythms in clock gene expression in the dorsomedial hypothalamic nucleus (DMH), a putative food-entrained circadian oscillator. To study this concept further, we made food availability unpredictable by presenting the meal at a random time each day (variable restricted feeding, VRF), either during the day, night or throughout the 24-h cycle. Wheel running activity and the expression of the clock protein, Period1 (PER1), in the DMH and the suprachiasmatic nucleus (SCN) were assessed. Rats exhibited increased levels of activity during the portion of the day when food was randomly presented but, as expected, failed to entrain anticipatory wheel running activity to a single time of day. PER1 expression in the SCN was unchanged by VRF schedules. In the DMH, PER1 expression became rhythmic, peaking at opposite times of day in rats fed only during the day or during the night. In rats fed randomly throughout the entire 24-h cycle, PER1 expression in the DMH remained arrhythmic, but was elevated. These results demonstrate that VRF schedules confined to the day or night can induce circadian rhythms of clock gene expression in the DMH. Such feeding schedules cannot entrain behavioral rhythms, thereby showing that food-entrainment of behavior and circadian rhythms of clock gene expression in the DMH are dissociable.
机译：当食物的供应仅限于一天中的某个时间时，啮齿动物的行为和生理的昼夜节律会发生变化，以预测食物到达的可预测时间。据推测，某些食物预期节律与背体下丘脑核（DMH）（假定的食物携带昼夜节律振荡器）中时钟基因表达的诱导和携带有关。为了进一步研究这一概念，我们通过在白天，晚上或整个24小时周期中每天随机提供一餐（可变受限喂食，VRF）来使食物供应量无法预测。评估了车轮行驶活动和DMH和视交叉上核（SCN）中时钟蛋白Period1（PER1）的表达。在随机提供食物的那一天中，大鼠表现出增加的活动水平，但是，正如预期的那样，未能在一天中的某个时间夹带预期的滚轮运行活动。通过VRF计划，SCN中的PER1表达不变。在DMH中，PER1的表达变得有节奏，仅在白天或晚上喂食的大鼠在一天的相对时间达到峰值。在整个24小时周期内随机进食的大鼠中，DMH中的PER1表达仍心律不齐，但升高。这些结果表明，仅限于白天或晚上的VRF时间表可以在DMH中诱导时钟基因表达的昼夜节律。这样的喂食时间表不能使行为节律带走，从而表明DMH中食物的行为带动和时钟基因表达的昼夜节律是可分离的。

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