...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons.
【24h】

Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons.

机译：感觉剥夺调节听觉脑干神经元中的超极化激活电流的发展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are highly expressed in the superior olivary complex, the primary locus for binaural information processing. This hyperpolarization-activated current (I(h)) regulates the excitability of neurons and enhances the temporally precise analysis of the binaural acoustic cues. By using the whole-cell patch-clamp technique, we examined the properties of I(h) current in neurons of the lateral superior olive (LSO) and the medial nucleus of the trapezoid body (MNTB) before and after hearing onset. Moreover, we tested the hypothesis that I(h) currents are actively regulated by sensory input activity by performing bilateral and unilateral cochlear ablations before hearing onset, resulting in a chronic auditory deprivation. The results show that after hearing onset, I(h) currents are rapidly upregulated in LSO neurons, but change only marginally in neurons of the MNTB. We also found a striking difference in maximal current density, voltage dependence and activation time constant between the LSO and the MNTB in mature-like animals. Following bilateral cochlear ablations before hearing onset, the I(h) currents were scaled up in the LSO and scaled down in the MNTB. Consequently, in the LSO this resulted in a depolarized resting membrane potential and a lower input resistance of these neurons. This type of activity-dependent homeostatic change could thus result in an augmented response to the remaining inputs.
机译：超极化激活和环状核苷酸门控（HCN）通道在上层橄榄复合体（双耳信息处理的主要场所）中高度表达。这种超极化激活电流（I（h））调节神经元的兴奋性，并增强了双耳声学提示的时间精确分析。通过使用全细胞膜片钳技术，我们在发作前后检查了外侧上橄榄（LSO）和梯形体内侧核（MNTB）的神经元中I（h）电流的特性。此外，我们通过听觉发作之前进行双侧和单侧耳蜗消融测试了I（h）电流受感觉输入活动积极调节的假说，导致慢性听觉剥夺。结果表明，听觉发作后，I（h）电流在LSO神经元中迅速上调，但在MNTB神经元中仅发生少量变化。我们还发现，在类似成熟动物的LSO和MNTB之间，最大电流密度，电压依赖性和激活时间常数之间存在显着差异。听力发作前双侧耳蜗消融后，LSO中的I（h）电流增大，而MNTB中的I（h）电流减小。因此，在LSO中，这会导致去极化的静息膜电位和这些神经元的较低输入电阻。因此，这种类型的活动相关的稳态变化可能导致对其余输入的响应增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号