Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system.

Nautiyal M; Sweatt AJ; MacKenzie JA; Mark Payne R; Szucs S; Matalon R; Wallin R; Hutson SM

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Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system.

机译：线粒体蛋白NIPSNAP1在大鼠神经系统中的神经元定位。

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The NIPSNAP (4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1) proteins belong to a highly conserved family of proteins of unknown function. We found that NIPSNAP1 binds to the branched-chain alpha-keto acid (BCKA) dehydrogenase enzyme complex, which is disrupted in maple syrup urine disease, a disease of branched-chain amino acid catabolism that results in neurological dysfunction. Phenylketonuric (PKU) and epileptic mice show altered expression of NIPSNAP1 in the brain. Therefore, the distribution and localization of NIPSNAP1 in rat brain was determined. Results show that NIPSNAP1 is expressed exclusively in neurons including pyramidal neurons in the cerebral cortex, Purkinje neurons in the cerebellum and motor neurons in the spinal cord. Dopaminergic neurons in midbrain and noradrenergic neurons in the brainstem, which are affected in PKU, also express NIPSNAP1. NIPSNAP1 is found to be localized in the mitochondrial matrix and can bind dihydrolipoyl-transacylase and -transacetylase components of the BCKA and pyruvate dehydrogenase complexes in vitro. Our data provide the first experimental evidence for a strictly neuronal expression of this mitochondrial protein in the rat nervous system.

机译：NIPSNAP（4-硝基苯基磷酸酶结构域和非神经元SNAP25样蛋白同源物1）蛋白属于功能未知的高度保守的蛋白家族。我们发现，NIPSNAP1与支链α-酮酸（BCKA）脱氢酶复合物结合，后者在枫糖浆尿病（一种导致神经功能障碍的支链氨基酸分解代谢疾病）中被破坏。苯丙酮尿症（PKU）和癫痫小鼠显示NIPSNAP1在大脑中的表达发生了改变。因此，确定了NIPSNAP1在大鼠脑中的分布和定位。结果显示，NIPSNAP1仅在神经元中表达，包括大脑皮质的锥体神经元，小脑的Purkinje神经元和脊髓的运动神经元。在PKU中受影响的中脑中的多巴胺能神经元和脑干中的去甲肾上腺素能神经元也表达NIPSNAP1。 NIPSNAP1被发现位于线粒体基质中，并可以在体外结合BCKA的二氢脂酰-转酰化酶和-反乙酰化酶成分以及丙酮酸脱氢酶复合物。我们的数据为线粒体蛋白在大鼠神经系统中的严格神经元表达提供了第一个实验证据。

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《The European Journal of Neuroscience》 |2010年第4期|共10页
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Nautiyal M; Sweatt AJ; MacKenzie JA; Mark Payne R; Szucs S; Matalon R; Wallin R; Hutson SM;
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中图分类神经病学与精神病学;
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1. Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system. [J] . Nautiyal M, Sweatt AJ, MacKenzie JA, The European Journal of Neuroscience . 2010,第4期

机译：线粒体蛋白NIPSNAP1在大鼠神经系统中的神经元定位。
2. Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system. [J] . Nagata K, Kiryu Seo S, Kiyama H Neuroscience: An International Journal under the Editorial Direction of IBRO . 2006,第1期

机译：大鼠神经系统中损伤诱导神经元内肽酶mRNA表达神经元的定位和个体发育。
3. Localization and neuronal response of RFamide related peptides in the rat central nervous system. [J] . Yano T, Iijima N, Kakihara K, Brain research . 2003,第2期

机译：RFamide相关肽在大鼠中枢神经系统中的定位和神经元反应。
4. Use of selective silver impregnation of neuronal degeneration as a biomarker for assessing organophosphorus-induced neuropathy in the central nervous system. a review [C] . Duke Tanaka, Steven J. Bursian, American Society for Testing and Materials Symposium on toxicology and risk assessment: Ultraviolet radiation and the environment . 1998

机译：使用选择性银浸渍神经元变性作为生物标志物，用于评估中枢神经系统中有机磷诱导的神经病变。回顾
5. Cell type-specific and stress-dependent expression of the small heat shock protein Hsp27 in the adult rat central nervous system. [D] . Krueger-Naug, Anne Marie Renee. 2002

机译：小热休克蛋白Hsp27在成年大鼠中枢神经系统中的细胞类型特异性和应激依赖性表达。
6. Neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH): immunological detection and neuronal localization in insect central nervous system. [O] . C A Bishop, M OShea, R J Miller 1981

机译：神经肽直肠蛋白（H-Arg-Tyr-Leu-Pro-Thr-OH）：昆虫中枢神经系统的免疫学检测和神经元定位。
7. Neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH): immunological detection and neuronal localization in insect central nervous system. [O] . C. A. Bishop, M. OShea, R. J. Miller 1981

机译：神经肽吡啶（H-Arg-Tyr-Leu-Pro-Thr-OH）：昆虫中枢神经系统中的免疫检测和神经元定位。

Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system.

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