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首页> 外文期刊>The European Journal of Neuroscience >Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina.
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Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina.

机译：啮齿类动物视网膜光感受器突触中AMPA谷氨酸受体亚基的异质分布。

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摘要

In the retina the segregation of different aspects of visual information starts at the first synapse in signal transfer from the photoreceptors to the second-order neurons, via the neurotransmitter glutamate. We examined the distribution of the four AMPA glutamate receptor subunits GluR1-GluR4 at the photoreceptor synapses in mouse and rat retinae by light and immunoelectron microscopy and serial section reconstructions. On the dendrites of OFF-cone bipolar cells, which make flat, noninvaginating contacts postsynaptic at cone synaptic terminals, the subunits GluR1 and GluR2 were predominantly found. Horizontal cell processes postsynaptic at both rod and cone synaptic terminals preferentially expressed the subunits GluR2, GluR2/3 and GluR4. An intriguing finding was the presence of GluR2/3 and GluR4 subunits on dendrites of putative rod bipolar cells, which are thought to signal through the sign-inverting metabotropic glutamate receptor 6, mGluR6. Furthermore, at the rod terminals, horizontal cell processes and rod bipolar cell dendrites showed labelling for the AMPA receptor subunits at the ribbon synaptic site or perisynaptically at their site of invagination into the rod terminal. The wide distribution of AMPA receptor subunits at the photoreceptor synapses suggests that AMPA receptors play an important role in visual signal transfer from the photoreceptors to their postsynaptic partners.
机译：在视网膜中，视觉信息的不同方面的分离始于通过神经递质谷氨酸从光感受器到二阶神经元的信号传递中的第一突触。我们通过光学和免疫电子显微镜及连续切片重建检查了小鼠和大鼠视网膜中光感受器突触处的四个AMPA谷氨酸受体亚基GluR1-GluR4的分布。在OFF锥双极细胞的树突上，它们在锥体突触末端突触后形成扁平的，无侵害的接触，主要发现了亚基GluR1和GluR2。在杆和锥突触末端的突触后水平细胞过程优先表达亚基GluR2，GluR2 / 3和GluR4。一个有趣的发现是推定的杆双极细胞的树突上存在GluR2 / 3和GluR4亚基，这些亚基被认为通过信号转化型代谢型谷氨酸受体6 mGluR6发出信号。此外，在杆末端，水平细胞过程和杆双极细胞树突显示出在带状突触位点或在其内陷到杆末端的位点突触地标记AMPA受体亚基。 AMPA受体亚基在光感受器突触处的广泛分布表明，AMPA受体在视觉信号从光感受器传递到突触后伙伴中起着重要作用。

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