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首页> 外文期刊>The European Journal of Neuroscience >Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific.
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Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific.

机译：大鼠前额叶皮层中多唾液酸化神经细胞粘附分子表达的学习相关调节是区域，细胞类型和范例特异性的。

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The prefrontal cortex (PFC) is an interconnected set of cortical areas that function in the synthesis of a diverse range of information and production of complex behaviour. It is now clear that these frontal structures, through bidirectional excitatory communication with the hippocampal formation, also play a substantial role in long-term memory consolidation. In the hippocampus, morphological synaptic plasticity, supported by regulation of neural cell adhesion molecule (NCAM) polysialylation status, is crucial to information storage. The recent description of polysialylated neurons in the various fields of the medial PFC suggests these structures to possess a similar capacity for synaptic plasticity. Here, using double-labelling immunohistochemistry with glutamic acid decarboxylase 67, we report that the nature of NCAM polysialic acid-positive neurons in the PFC is region-specific, with a high proportion (30-50%) of a gamma-aminobutyric acid (GABA)ergic phenotype in the more ventral infralimbic, orbitofrontal and insular cortices compared with just 10% in the dorsal structures of the cingulate, prelimbic and frontal cortices. Moreover, spatial learning was accompanied by activations in polysialylation expression in ventral PFC structures, while avoidance conditioning involved downregulation of this plasticity marker that was restricted to the dorsomedial PFC--the cingulate and prelimbic cortices. Thus, in contrast to other structures integrated functionally with the hippocampus, memory-associated plasticity mobilized in the PFC is region-, cell type- and task-specific.
机译：前额叶皮层（PFC）是一组相互连接的皮质区域，在合成各种信息和产生复杂行为方面起作用。现在清楚的是，这些额叶结构通过与海马结构的双向兴奋性交流，在长期记忆巩固中也起着重要作用。在海马中，由神经细胞粘附分子（NCAM）多唾液酸化状态的调节支持的形态学突触可塑性对于信息存储至关重要。在内侧PFC各个领域中对多唾液酸化神经元的最新描述表明，这些结构具有类似的突触可塑性能力。在这里，我们使用带有谷氨酸脱羧酶67的双标记免疫组织化学方法，我们报告说PFC中NCAM聚唾液酸阳性神经元的性质是区域特异性的，其中γ-氨基丁酸（ GABA能表型在腹侧下缘，眶额皮质和岛状皮质较多，而扣带状，前缘和额叶皮质的背侧结构仅为10％。此外，空间学习伴随着腹侧PFC结构中多唾液酸化表达的激活，而回避条件则涉及该可塑性标记的下调，该标记仅限于背侧PFC——扣带状和前缘皮层。因此，与在功能上与海马整合在一起的其他结构相反，在PFC中动员的与记忆相关的可塑性是区域，细胞类型和任务特定的。

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