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首页> 外文期刊>The European Journal of Neuroscience >Reduced saccadic resilience and impaired saccadic adaptation due to cerebellar disease.
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Reduced saccadic resilience and impaired saccadic adaptation due to cerebellar disease.

机译：由于小脑疾病而导致的韧带复原力降低，以及韧带适应能力受损。

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The term short-term saccadic adaptation (STSA) captures our ability to unconsciously move the endpoint of a saccade to the final position of a visual target that has jumped to a new location during the saccade. STSA depends on the integrity of the cerebellar vermis. We tested the hypothesis that STSA reflects the working of a cerebellar mechanism needed to avoid 'fatigue', a gradual drop in saccade amplitude during a long series of stereotypic saccades. To this end we compared the kinematics of saccades of 14 patients suffering from different forms of cerebellar disease with those of controls in two tests of STSA and a test of saccadic resilience. Controls showed an increase in saccade amplitude (SA) for outward adaptation, prompted by outward target shifts, due to an increase in saccade duration (SD) in the face of constant peak velocity (PV). The decrease in SA due to inward adaptation was, contrariwise, accompanied by a drop in PV and SD. Whereas patients with intact vermis did not differ from controls, those with vermal pathology lacked outward adaptation: SD remained constant, as did SA and PV. In contrast, vermal patients demonstrated a significant decrease in SA, paralleled by a decrease in PV but mostly unaltered SD in the inward adaptation experiment as well as in the resilience test. These findings support the notion that inward adaptation is at least partially based on uncompensated fatigue. On the other hand, outward adaptation reflects an active mechanism for the compensation of fatigue, residing in the cerebellum.
机译：术语短期眼跳适应（STSA）捕捉了我们无意识地将扫视运动的端点移动到视觉目标的最终位置的能力，该目标在扫视过程中已跳至新的位置。 STSA取决于小脑ver骨的完整性。我们测试了以下假设：STSA反映了避免“疲劳”所需的小脑机制的作用，疲劳是在一系列定型扫视过程中扫视幅度的逐渐下降。为此，我们在两次STSA测试和对视弹性的测试中比较了14位患有不同形式的小脑疾病的患者的扫视运动学与对照组的运动学。对照显示，由于面对恒定峰值速度（PV）时扫视时间（SD）的增加，向外目标的移动促使扫视幅度（​​SA）的增加。相反，由于向内适应而导致的SA下降伴随着PV和SD下降。 ver骨完整的患者与对照组没有差异，而，骨病理的患者缺乏外向适应性：SD保持恒定，SA和PV也保持恒定。相反，在向内适应性实验和适应力测试中，正常患者的SA显着降低，同时PV降低，但SD几乎没有改变。这些发现支持以下观点：向内适应至少部分基于无补偿的疲劳。另一方面，外向适应反映了一种活跃的机制，可以补偿小脑中的疲劳。

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