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首页> 外文期刊>The European Journal of Neuroscience >Imbalance between excitation and inhibition among synaptic connections of CA3 pyramidal neurons in cultured hippocampal slices.
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Imbalance between excitation and inhibition among synaptic connections of CA3 pyramidal neurons in cultured hippocampal slices.

机译：在培养的海马切片中，CA3锥体神经元的突触连接之间的兴奋和抑制之间的失衡。

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摘要

A fundamental property of small neuronal ensembles is their ability to be selectively activated by distinct stimuli. One cellular mechanism by which neurons achieve this input selectivity is by modulating the temporal dynamics of excitation and inhibition. We explored the interplay of excitation and inhibition in synapses between pyramidal neurons of cornu ammonis field 3 of the hippocampal formation (CA3) in cultured rat hippocampal slices, where activation of a single excitatory cell can readily recruit local interneurons. Simultaneous whole-cell recordings from pairs of CA3 pyramidal neurons revealed that the strength of connections was neither uniform nor balanced. Rather, stimulation of presynaptic neurons elicited distinct combinations of excitatory postsynaptic current-inhibitory postsynaptic current (EPSC-IPSC) amplitudes in the postsynaptic neurons. EPSC-IPSC sequences with small EPSCs had large IPSCs and sequences that contained large EPSCs had small IPSCs. In addition to differences in the amplitudes of the responses, the kinetics of the EPSCs were also different, creating distinct temporal dynamics of excitation and inhibition. Weaker EPSCs had significantly slower kinetics and were efficiently occluded by IPSCs, thereby further limiting their contribution to depolarizing the postsynaptic membrane. Our data suggest that hippocampal pyramidal cells may use an imbalance between excitation and inhibition as a filter to enhance selectivity toward preferential excitatory connections.
机译：小神经元合奏的基本特性是它们被独特的刺激选择性激活的能力。神经元实现此输入选择性的一种细胞机制是通过调节兴奋和抑制的时间动态。我们探讨了在培养的大鼠海马切片中海马结构的角膜羊膜域3角锥体神经元（CA3）的锥体神经元之间的突触之间的相互作用，其中单个兴奋性细胞的活化可以很容易地募集局部中神经元。来自成对的CA3锥体神经元的全细胞记录同时显示，连接强度既不均匀也不平衡。而是，突触前神经元的刺激引起突触后神经元中兴奋性突触后电流抑制性突触后电流（EPSC-IPSC）幅度的不同组合。具有小EPSC的EPSC-IPSC序列具有较大的IPSC，而包含大EPSC的序列具有较小的IPSC。除了响应幅度不同外，EPSC的动力学也不同，从而产生了不同的激发和抑制时间动态。较弱的EPSC动力学显着变慢，并且被IPSC有效地封闭，从而进一步限制了它们对突触后膜去极化的作用。我们的数据表明，海马锥体细胞可能使用兴奋和抑制之间的不平衡作为过滤器，以增强对优先兴奋性连接的选择性。

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