...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Nociceptive spinothalamic tract and postsynaptic dorsal column neurons are modulated by paraventricular hypothalamic activation.
【24h】

Nociceptive spinothalamic tract and postsynaptic dorsal column neurons are modulated by paraventricular hypothalamic activation.

机译：伤害性的丘脑束道和突触后背柱神经元受室旁下丘脑激活的调节。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previously, we demonstrated that stimulation of the paraventricular hypothalamic nucleus diminishes the nociceptive dorsal horn neuronal responses, and this decrease was mediated by oxytocin in the rat. In addition, we have proposed that oxytocin indirectly inhibits sensory transmission in dorsal horn neurons by exciting spinal inhibitory GABAergic interneurons. The main purpose of the present study was to identify which of the neurons projecting to supraspinal structures to transmit somatic information are modulated by the hypothalamic-spinal descending activation. In anaesthetized rats, single-unit extracellular and juxtacellular recordings were made from dorsal horn lumbar segments, which receive afferent input from the toe and hind-paw regions. The projecting spinothalamic tract and postsynaptic dorsal column system were identified antidromically. Additionally, in order to label the projecting dorsal horn neurons, we injected fluorescent retrograde neuronal tracers into the ipsilateral gracilis nucleus and contralateral ventroposterolateral thalamic nucleus. Hence, juxtacellular recordings were made to iontophoretically label the recorded neurons with a fluorescent dye and identify the recorded projecting cells. We found that only nociceptive evoked responses in spinothalamic tract and postsynaptic dorsal column neurons were significantly inhibited (48.1 +/- 4.6 and 47.7 +/- 8.2%, respectively) and non-nociceptive responses were not affected by paraventricular hypothalamic nucleus stimulation. We conclude that the hypothalamic-spinal system selectively affects the transmission of nociceptive information of projecting spinal cord cells.
机译：以前，我们证明了对脑室下丘脑旁核的刺激减少了伤害感受性背角神经元反应，而这种减少是由催产素介导的。另外，我们已经提出，催产素通过激发脊髓抑制性GABA能中间神经元间接抑制背角神经元的感觉传递。本研究的主要目的是确定下丘脑-脊髓下行激活调节投射到脊髓上结构以传递体细胞信息的神经元。在麻醉的大鼠中，从背角腰段获取单细胞外和近细胞记录，它们从脚趾和后爪区域接收传入的输入。突触的丘脑束道和突触后背柱系统被反辨认。此外，为了标记突出的背角神经元，我们将荧光逆行神经元示踪剂注入到同侧的舌状核和对侧的腹侧腹外侧丘脑核中。因此，进行了近细胞记录以用荧光染料离子电标记记录的神经元并鉴定记录的投射细胞。我们发现，只有在丘脑丘脑和突触后背柱神经元的伤害性诱发反应被显着抑制（分别为48.1 +/- 4.6和47.7 +/- 8.2％），非伤害性反应不受脑室下丘脑旁核刺激的影响。我们得出的结论是，下丘脑-脊髓系统选择性影响投射脊髓细胞的伤害性信息的传递。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号