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首页> 外文期刊>The European Journal of Neuroscience >Suppression of visual cortical evoked responses following deprivation of pattern vision in adult mice.
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Suppression of visual cortical evoked responses following deprivation of pattern vision in adult mice.

机译：成年小鼠的视力丧失后，视觉皮层诱发的反应受到抑制。

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The effect of visual loss on the adult neocortex can have significant impact on the success of a visual implant. Recent research has shown that the adult neocortex retains substantial plasticity following a disruption to its afferent input. The result of these changes may hamper the development of a visual prosthesis if visual sensation cannot be effectively restored by stimulation of the surviving elements of the visual pathway. In order to evaluate further the visual performance of the mammalian adult brain following visual loss, especially the dominant form of blindness in humans, namely loss of pattern vision, we examined the cortical evoked potential of adult mice following 7, 30 and 120 days of visual deprivation via bilateral eyelid suture. Cortical potentials were elicited with a flash visual stimulus or by electrical stimulation of the retina. We found that after 7 days deprivation there was a potentiation of the evoked response while at 30 and 120 days deprivation the visual evoked responses were significantly reduced. Increasing the visual stimulus intensity reduced the effects. The electrical evoked potential demonstrated a corresponding reduction in stimulus threshold at 7 days and a corresponding rise (40-50%) after 30 and 120 days. These findings suggest that the adult brain exhibited significant experience-dependent modifications following visual loss, and the impact depended on the duration of deprivation. Such reduction in visual responsiveness, especially with electrical activation, will need to be taken into account in the development of a visual implant.
机译：视力丧失对成人新皮层的影响可能对视力植入物的成功产生重大影响。最近的研究表明，成年新皮层在传入输入中断后仍保持可塑性。如果不能通过刺激视觉通路中存活的元件有效地恢复视觉，这些变化的结果可能会阻碍视觉修复的发展。为了进一步评估视力丧失后哺乳动物成年大脑的视觉表现，尤其是人类失明的主要形式，即模式视力丧失，我们研究了成年小鼠在视觉第7、30和120天后的皮质诱发电位双侧眼睑缝合剥夺。皮质电位是通过闪光的视觉刺激或视网膜的电刺激而引起的。我们发现剥夺7天后，诱发的反应增强，而剥夺30天和120天时，视觉诱发的反应明显降低。视觉刺激强度的增加会降低效果。诱发电势在7天时显示相应的刺激阈值降低，在30天和120天后相应升高（40-50％）。这些发现表明，成年大脑在视力丧失后表现出明显的经验依赖性修饰，其影响取决于剥夺的持续时间。在视觉植入物的开发中将需要考虑这种视觉响应性的降低，尤其是在电激活的情况下。

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