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首页> 外文期刊>The European Journal of Neuroscience >Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose
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Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose

机译：可卡因节制在可卡因和蔗糖的目标行为期间改变伏隔核激发动力学

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Distinct subsets of nucleus accumbens (NAc) neurons differentially encode goal-directed behaviors for natural vs. drug rewards [R. M. Carelli (2000)The Journal of Neuroscience, 20, 4255-4266], and the encoding of cocaine-seeking is altered following cocaine abstinence [J. A. Hollander & R. M. Carelli (2007) The Journal of Neuroscience, 27, 3535-3539]. Here, electrophysiological recording procedures were used to determine if the selective encoding of natural vs. cocaine reward by NAc neurons is: (i) maintained when the natural reinforcer is a highly palatable sweet tastant and (ii) altered by cocaine abstinence. Rats (n=14) were trained on a multiple schedule of sucrose reinforcement and cocaine self-administration (2-3weeks) and NAc activity was recorded during the task before and after 30days of cocaine abstinence. Of 130 cells recorded before abstinence, 82 (63%) displayed patterned discharges (increases or decreases in firing rate, termed phasic activity) relative to operant responding for sucrose or cocaine. As in previous reports, the majority of those cells displayed nonoverlapping patterns of activity during responding for sucrose vs. cocaine. Specifically, only 17 (21%) showed similar patterns of activity (i.e. overlapping activity) across the two reinforcer conditions. After abstinence, this pattern was largely maintained, 23 of 70 phasic cells (33%) were overlapping. However, cocaine abstinence altered the overall percentage of selectively active neurons across reinforcer conditions. Specifically, significantly more neurons became selectively activated during cocaine-directed behaviors than during sucrose-directed behaviors. The results indicate that, although the selective encoding of cocaine and natural rewards is maintained even with a highly palatable substance, 30days of cocaine abstinence dynamically alters the overall population encoding of natural and drug rewards by NAc neurons.
机译：伏伏核（NAc）神经元的不同子集以差分方式编码自然与药物奖励的目标导向行为[R. M. Carelli（2000）The Journal of Neuroscience，20，4255-4266]，并且在戒除可卡因后改变了寻找可卡因的编码[J. A. Hollander＆R. M. Carelli（2007）神经科学杂志，27，3535-3539]。在这里，使用电生理记录程序来确定NAc神经元对自然与可卡因报酬的选择性编码是否为：（i）当天然增强剂是高度可口的甜味剂时保持;以及（ii）通过可卡因戒断而改变。对大鼠（n = 14）进行多次蔗糖强化和可卡因自我给药（2-3周）训练，并且在禁食30天之前和之后记录任务期间的NAc活性。相对于操作者对蔗糖或可卡因的反应，在禁欲前记录的130个细胞中，有82个（63％）显示出模式放电（放电率增加或降低，称为阶段性活动）。如以前的报告所述，在蔗糖与可卡因反应期间，这些细胞中的大多数显示出不重叠的活性模式。具体而言，在两种补强剂条件下，只有17个（21％）表现出相似的活动模式（即重叠活动）。禁酒后，这种模式得到了很大的维持，70个相细胞中有23个（33％）重叠。然而，可卡因禁欲改变了强化剂条件下选择性活跃神经元的总体百分比。具体而言，在可卡因指导的行为中，比在蔗糖指导的行为中有更多的神经元被选择性激活。结果表明，尽管即使使用高度可口的物质也可以保持可卡因和自然奖励的选择性编码，但禁食30天可卡因会动态改变NAc神经元对自然和药物奖励的总体编码。

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