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首页> 外文期刊>The European Journal of Neuroscience >Striatal dopamine modulates song spectral but not temporal features through D1 receptors
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Striatal dopamine modulates song spectral but not temporal features through D1 receptors

机译：纹状体多巴胺通过D1受体调节歌曲谱，但不调节时间特征

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The activity of midbrain dopaminergic neurons and their projection to the basal ganglia (BG) are thought to play a critical role in the acquisition of motor skills through reinforcement learning, as well as in the expression of learned motor behaviors. The precise role of BG dopamine (DA) in mediating and modulating motor performance and learning, however, remains unclear. In songbirds, a specialized portion of the BG is responsible for song learning and plasticity. Previously we found that DA acts on D1 receptors in Area X to modulate the BG output signal and thereby trigger changes in song variability. Here, we investigate the effect of D1 receptor blockade in the BG on song behavior in the zebra finch. We report that this manipulation abolishes social context-dependent changes in variability not only in harmonic stacks, but also in other types of syllables. However, song timing seems not to be modulated by this BG DA signal. Indeed, injections of a D1 antagonist in the BG altered neither song duration nor the change of song duration with social context. Finally, D1 receptor activation in the BG was not necessary for the modulation of other features of song, such as the number of introductory notes or motif repetitions. Together, our results suggest that activation of D1 receptors in the BG is necessary for the modulation of fine acoustic features of song with social context, while it is not involved in the regulation of song timing and structure at a larger time scale. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
机译：中脑多巴胺能神经元的活动及其向基底神经节（BG）的投射被认为在通过强化学习获得运动技能以及表达所学运动行为中起关键作用。然而，尚不清楚BG多巴胺（DA）在介导和调节运动表现和学习中的确切作用。在鸣禽中，BG的专门部分负责歌曲的学习和可塑性。以前，我们发现DA作用于X区域的D1受体以调节BG输出信号，从而触发歌曲可变性的变化。在这里，我们研究了BG中D1受体阻滞对斑马雀科歌曲行为的影响。我们报告说，这种操纵不仅消除了谐波上下文中其他变量的变化，还消除了社会背景相关的变化。但是，歌曲定时似乎不受此BG DA信号的调制。确实，在BG中注入D1拮抗剂不会改变歌曲持续时间，也不会随着社交环境改变歌曲持续时间。最后，BG中的D1受体激活对于调节歌曲的其他特征（如介绍性音符或基序重复的数目）不是必需的。总之，我们的研究结果表明，在BG中激活D1受体对于调节具有社交环境的歌曲的精细声学特征是必要的，而在更大的时间范围内，它并不参与歌曲时间和结构的调节。 2012年发布。本文是美国政府的工作，在美国属于公共领域。

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