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首页> 外文期刊>The European Journal of Neuroscience >Frequency matters: Beta-band subthalamic nucleus deep-brain stimulation induces Parkinsonian-like blink abnormalities in normal rats
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Frequency matters: Beta-band subthalamic nucleus deep-brain stimulation induces Parkinsonian-like blink abnormalities in normal rats

机译：频率问题：β带丘脑丘脑底核深脑刺激诱发正常大鼠帕金森氏样眨眼异常

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摘要

The synchronized beta-band oscillations in the basal ganglia-cortical networks in Parkinson's disease (PD) may be responsible for PD motor symptoms or an epiphenomenon of dopamine loss. We investigated the causal role of beta-band activity in PD motor symptoms by testing the effects of beta-frequency subthalamic nucleus deep-brain stimulation (STN DBS) on the blink reflex excitability, amplitude, and plasticity in normal rats. Delivering 16 Hz STN DBS produced the same increase in blink reflex excitability and impairment in blink reflex plasticity in normal rats as occurs in rats with 6-hydroxydopamine lesions and patients with PD. These deficits were not an artifact of STN DBS because, when these normal rats received 130 Hz STN DBS, their blink characteristics were the same as without STN DBS. To demonstrate that the blink reflex disturbances with 16 Hz STN DBS were frequency specific, we tested the same rats with 7 Hz STN DBS, a theta-band frequency typical of dystonia. In contrast to beta stimulation, 7 Hz STN DBS exaggerated the blink reflex plasticity as occurs in focal dystonia. Thus, without destroying dopamine neurons or blocking dopamine receptors, frequency-specific STN DBS can be used to create PD-like or dystonic-like symptoms in a normal rat.
机译：帕金森氏病（PD）的基底神经节-皮层网络中同步的β波段振荡可能是PD运动症状或多巴胺流失的表象。我们通过测试β频率丘脑下丘脑核深脑刺激（STN DBS）对正常大鼠眨眼反射兴奋性，幅度和可塑性的影响，研究了β带活动在PD运动症状中的因果作用。在正常大鼠中，传递16 Hz STN DBS会产生眨眼反射兴奋性增加和眨眼反射可塑性受损的现象，这与6-羟基多巴胺损伤的大鼠和PD患者的情况相同。这些缺陷不是STN DBS的假象，因为当这些正常大鼠接受130 Hz STN DBS时，其眨眼特征与没有STN DBS时相同。为了证明16 Hz STN DBS的眨眼反射障碍是特定频率的，我们用7 Hz STN DBS（肌张力障碍典型的theta-band频率）测试了同一只大鼠。与beta刺激相反，7 Hz STN DBS夸大了局灶性肌张力障碍中的眨眼反射可塑性。因此，在不破坏多巴胺神经元或阻断多巴胺受体的情况下，频率特异性STN DBS可用于在正常大鼠中产生PD样或肌张力障碍样症状。

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