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首页> 外文期刊>The European Journal of Neuroscience >Selective importance of the rat anterior thalamic nuclei for configural learning involving distal spatial cues
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Selective importance of the rat anterior thalamic nuclei for configural learning involving distal spatial cues

机译：大鼠前丘脑核对涉及远端空间线索的形态学习的选择性重要性

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To test potential parallels between hippocampal and anterior thalamic function, rats with anterior thalamic lesions were trained on a series of biconditional learning tasks. The anterior thalamic lesions did not disrupt learning two biconditional associations in operant chambers where a specific auditory stimulus (tone or click) had a differential outcome depending on whether it was paired with a particular visual context (spot or checkered wall-paper) or a particular thermal context (warm or cool). Likewise, rats with anterior thalamic lesions successfully learnt a biconditional task when they were reinforced for digging in one of two distinct cups (containing either beads or shredded paper), depending on the particular appearance of the local context on which the cup was placed (one of two textured floors). In contrast, the same rats were severely impaired at learning the biconditional rule to select a specific cup when in a particular location within the test room. Place learning was then tested with a series of goo-go discriminations. Rats with anterior thalamic nuclei lesions could learn to discriminate between two locations when they were approached from a constant direction. They could not, however, use this acquired location information to solve a subsequent spatial biconditional task where those same places dictated the correct choice of digging cup. Anterior thalamic lesions produced a selective, but severe, biconditional learning deficit when the task incorporated distal spatial cues. This deficit mirrors that seen in rats with hippocampal lesions, so extending potential interdependencies between the two sites.
机译：为了测试海马体与前丘脑功能之间的潜在相似性，对具有前丘脑病变的大鼠进行了一系列双条件学习任务训练。丘脑前部病变不会破坏手术室中的两种双条件关联，在这种情况下，特定的听觉刺激（音调或咔嗒声）的结果取决于其是否与特定的视觉环境（斑点或方格墙纸）或特定配对相匹配热环境（温暖或凉爽）。同样，对具有前丘脑病变的大鼠进行加固以在两个不同的杯子（包含小珠或碎纸）之一中进行挖掘时，成功地学会了一项双条件任务，具体取决于放置杯子的局部环境（一个两层纹理地板）。相反，当在测试室内的特定位置选择相同的杯子时，学习双条件规则的同一只大鼠受到严重损害。然后，对地方学习进行了一系列的通过/不通过判断。从恒定方向接近时，具有前丘脑核病变的大鼠可以学会区分两个位置。但是，他们无法使用此获取的位置信息来解决后续的空间双条件任务，因为这些位置决定了正确选择挖杯的位置。当任务纳入远端空间提示时，前丘脑病变会产生选择性但严重的双条件学习缺陷。这种缺陷反映了在海马损伤大鼠中所见的缺陷，因此扩大了两个部位之间潜在的相互依赖性。

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