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首页> 外文期刊>The European Journal of Neuroscience >Fixational saccacle-relatecl activity of pedunculopontine tegmental nucleus neurons in behaving monkeys
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Fixational saccacle-relatecl activity of pedunculopontine tegmental nucleus neurons in behaving monkeys

机译：行为猴中足底小腿被盖核神经元的固定性眼球相关活动

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摘要

Fixational saccades are small, involuntary eye movements that occur during attempted visual fixation. Recent studies suggested that several cognitive processes affect the occurrence probability of fixational saccades. Thus, there might be an interaction between fixational saccade-related motor signals and cognitive signals. The pedunculopontine tegmental nucleus (PPTN) in the brainstem has anatomical connections with numerous saccade-related and limbic areas. Previously, we reported that a group of PPTN neurons showed transient phasic bursts or a pause in activity during large visually guided and spontaneous saccades, and also showed sustained tonic changes in activity with task context. We hypothesised that single PPTN neurons would relay both fixational saccade-related and task context-related signals, and might function as an interface between the motor and limbic systems. We recorded the activity of PPTN neurons in behaving monkeys during a reward-biased task, and analysed neuronal activity for small fixational saccades during visual fixation, and compared it with the activity for large visually guided targeting saccades and large spontaneous saccades during intertrial intervals. A population of PPTN neurons exhibited a fixational saccade-related phasic increase in activity, and the majority of them also showed activity modulation with large targeting saccades. In addition, a group of these neurons showed a task-related tonic increase in activity during the fixation period, and half of them relayed the saccade signal only when the neuron exhibited higher tonic activity during the task execution period. Thus, fixational saccade-related signals of PPTN neurons overlap with tonic task-related signals, and might contribute to the cognitive modulation of fixational saccades.
机译：固定扫视是在尝试进行视力固定时发生的不自主的小眼球运动。最近的研究表明，几种认知过程会影响注视扫视的发生概率。因此，注视扫视相关运动信号和认知信号之间可能存在相互作用。脑干中的pedunculopontine被盖核（PPTN）与许多扫视相关和边缘区域具有解剖学联系。以前，我们报道了一组PPTN神经元在较大的视觉引导和自发扫视过程中表现出短暂的相位性爆发或活动暂停，并且在任务背景下也表现出持续的补品变化。我们假设单个PPTN神经元将中继与固视扫视相关和任务情境相关的信号，并且可能充当运动系统和边缘系统之间的接口。我们记录了奖励偏向任务中行为猴子的PPTN神经元的活动，并分析了视觉固定过程中小固定扫视的神经元活动，并将其与较大的视觉引导目标扫视和大自发扫视的活动间隔进行了比较。一群PPTN神经元表现出固定性扫视相关的活动性增加，并且大多数人还显示出针对大扫视的活动调节。此外，一组这些神经元在固定期间显示出与任务相关的紧张性活动的增加，其中只有当神经元在任务执行期间表现出较高的紧张性活动时，它们中的一半才传递扫视信号。因此，PPTN神经元的固视扫视相关信号与进补任务相关的信号重叠，并且可能有助于固视扫视的认知调节。

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