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首页> 外文期刊>The European Journal of Neuroscience >The fear circuit of the mouse forebrain: Connections between the mediodorsal thalamus, frontal cortices and basolateral amygdala
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The fear circuit of the mouse forebrain: Connections between the mediodorsal thalamus, frontal cortices and basolateral amygdala

机译：小鼠前脑的恐惧回路：腹中丘脑，额叶皮层和基底外侧杏仁核之间的连接

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A large forebrain circuit, including the thalamus, amygdala and frontal cortical regions, is responsible for the establishment and extinction of fear-related memories. Understanding interactions among these three regions is critical to deciphering the basic mechanisms of fear. With the advancement of molecular and optogenetics techniques, the mouse has become the main species used to study fear-related behaviours. However, the basic connectivity pattern of the forebrain circuits involved in processing fear has not been described in this species. In this study we mapped the connectivity between three key nodes of the circuit, i.e. the basolateral nucleus of the amygdala (BLA), the mediodorsal nucleus of the thalamus (MD) and the medial prefrontal cortex, which were shown to have closed triangular connectivity in rats. In contrast to rat, we found no evidence for this closed loop in mouse. There was no major input from the BLA to the MD and little overlap between medial prefrontal regions connected with both the BLA and MD. The common nodes in the frontal cortex, which displayed reciprocal connection with both the BLA and MD were the agranular insular cortex and the border zone of the cingulate and secondary motor cortex. In addition, the BLA can indirectly affect the MD via the orbital cortex. We attribute the difference between our results and earlier rat studies to methodological problems rather than to genuine species difference. Our data demonstrate that the BLA and MD communicate via cortical sectors, the roles in fear-related behaviour of which have not been extensively studied. In general, our study provides the morphological framework for studies of murine fear-related behaviours.
机译：包括丘脑，杏仁核和额叶皮层区域在内的大型前脑回路负责建立和消除与恐惧有关的记忆。了解这三个区域之间的相互作用对于破译恐惧的基本机制至关重要。随着分子和光遗传学技术的发展，小鼠已成为用于研究与恐惧有关的行为的主要物种。但是，该物种尚未描述涉及处理恐惧的前脑回路的基本连通性模式。在这项研究中，我们绘制了回路的三个关键节点之间的连通性，即杏仁核的基底外侧核（BLA），丘脑的中嗅核（MD）和前额叶内侧皮层，在这些区域中显示为闭合的三角形连通性。大鼠。与大鼠相反，我们没有发现小鼠闭环的证据。 BLA没有对MD的大量投入，并且与BLA和MD相连的内侧前额叶区域之间几乎没有重叠。额叶皮层中与BLA和MD都表现出相互联系的共同结节是颗粒状岛状皮层以及扣带状和次级运动皮层的边界区域。此外，BLA可通过眶皮质间接影响MD。我们将研究结果与早期大鼠研究之间的差异归因于方法学问题，而不是真正的物种差异。我们的数据表明，BLA和MD通过皮质部分进行通信，而在与恐惧相关的行为中的作用尚未得到广泛研究。一般而言，我们的研究为鼠类恐惧相关行为的研究提供了形态学框架。

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