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首页> 外文期刊>The European Journal of Neuroscience >Hippocampal interplay with the nucleus accumbens iscritical for decisions about time
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Hippocampal interplay with the nucleus accumbens iscritical for decisions about time

机译：海马与伏隔核的相互作用对于决定时间至关重要

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摘要

Human cognition depends upon the capacity to make decisions in the present that bear upon outcomes in the future. The nucleus accumbens, a recipient of direct projections from both the hippocampus and orbitofrontal cortex, is known to contribute to these aspects of decision-making. Here we demonstrate that interaction of the nucleus accumbens with the hippocampus, but not the orbitofrontal cortex, is critical in shaping decisions that involve time trade-offs. Compared with controls, rats with a disrupted hippocampal-accumbens interaction were strongly biased toward choosing stimuli that led to small and immediate food rewards over large and delayed ones. We show that this pattern of behavior cannot be ascribed to the impaired representation of stimulus value, the incapacity to wait, or a general disruption of decision-making. These results identify a hippocampal-accumbens circuit that may underlie a range of problems in which daily decisions are marked by a shift toward immediate gratification.
机译：人类的认知取决于当前做出决定的能力，而决定能力取决于未来的结果。伏隔核是海马体和眶额皮层直接投射的接受者，已知有助于决策的这些方面。在这里，我们证明伏隔核与海马而不是眶额皮层的相互作用在塑造涉及时间权衡的决策中至关重要。与对照组相比，海马-伏隔相互作用被破坏的大鼠强烈偏向于选择导致小额和即时食物奖励高于大额和延迟食物奖励的刺激。我们表明，这种行为模式不能归因于刺激价值的表征受损，等待能力不足或决策的普遍中断。这些结果表明，海马-伏隔回路可能是一系列问题的基础，在这些问题中，日常决策的重点是立即满足感。

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