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首页> 外文期刊>The European Journal of Neuroscience >Impairments in musical abilities reflected in the auditory brainstem: evidence from congenital amusia
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Impairments in musical abilities reflected in the auditory brainstem: evidence from congenital amusia

机译:听觉脑干中反映的音乐能力障碍:先天性失语的证据

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摘要

Congenital amusia is a neurogenetic condition, characterized by a deficit in music perception and production, not explained by hearing loss, brain damage or lack of exposure to music. Despite inferior musical performance, amusics exhibit normal auditory cortical responses, with abnormal neural correlates suggested to lie beyond auditory cortices. Here we show, using auditory brainstem responses to complex sounds in humans, that fine-grained automatic processing of sounds is impoverished in amusia. Compared with matched non-musician controls, spectral amplitude was decreased in amusics for higher harmonic components of the auditory brainstem response. We also found a delayed response to the early transient aspects of the auditory stimulus in amusics. Neural measures of spectral amplitude and response timing correlated with participants' behavioral assessments of music processing. We demonstrate, for the first time, that amusia affects how complex acoustic signals are processed in the auditory brainstem. This neural signature of amusia mirrors what is observed in musicians, such that the aspects of the auditory brainstem responses that are enhanced in musicians are degraded in amusics. By showing that gradients of music abilities are reflected in the auditory brainstem, our findings have implications not only for current models of amusia but also for auditory functioning in general.
机译:先天性失语是一种神经遗传性疾病,其特征是音乐知觉和音乐产生不足,无法用听力下降,脑损伤或缺乏音乐接触来解释。尽管音乐表现不佳,但音乐表现出正常的听觉皮层反应,并且异常的神经相关性被认为超出了听觉皮层。在这里,我们显示,使用听觉脑干对人类复杂声音的反应,声音的细粒度自动处理在失语症中是贫穷的。与匹配的非音乐家控制相比,听觉脑干反应的高次谐波分量的音乐频谱幅度减小。我们还发现对音乐中听觉刺激的早期瞬态方面的反应延迟。频谱幅度和响应时间的神经测量与参与者对音乐处理的行为评估相关。我们首次证明,失语症会影响听觉脑干中复杂声音信号的处理方式。失语症的这种神经特征反映了在音乐家中观察到的现象,从而使在音乐家中增强的听觉脑干反应的各方面在音乐性中退化。通过显示音乐能力的梯度反映在听觉脑干中,我们的发现不仅对当前的失语症模型有影响,而且对一般听觉功能也有影响。

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