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首页> 外文期刊>The European Journal of Neuroscience >Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner
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Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner

机译：Orexin / hypocretin神经元的激活与酒精的寻求和偏好在地形上相关

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Orexin (ORX) (also known as hypocretin) neurons are located exclusively in the posterior hypothalamus, and are involved in a wide range of behaviours, including motivation for drugs of abuse such as alcohol. Hypothalamic subregions contain functionally distinct populations of ORX neurons that may play different roles in regulating drug-motivated and alcohol-motivated behaviours. To investigate the role of ORX neurons in ethanol (EtOH) seeking, we measured Fos activation of ORX neurons in rats following three different measures of EtOH seeking and preference: (i) context-induced reinstatement, or ABA renewal; (ii) cue-induced reinstatement of extinguished responding for EtOH; and (iii) a home cage task in which preference for EtOH (vs. water) was measured in the absence of either reinforcer. We found significant activation of ORX neurons in multiple subregions across all three behavioural tests. Notably, ORX neuron activation in the lateral hypothalamus correlated with the degree of seeking in context reinstatement and the degree of preference in home cage preference testing. In addition, Fos activation in ORX neurons in the dorsomedial hypothalamic and perifornical areas was correlated with context and home cage seeking/preference, respectively. Surprisingly, we found no relationship between the degree of cue-induced reinstatement and ORX neuron activation in any region, despite robust activation overall during reinstatement. These results demonstrate a strong relationship between ORX neuron activation and EtOH seeking/preference, but one that is differentially expressed across ORX field subregions, depending on reinstatement modality.
机译：食欲素（ORX）（也称为降钙素）神经元仅位于下丘脑后部，并且涉及多种行为，包括滥用药物（如酒精）的动机。下丘脑子区域包含功能不同的ORX神经元群体，它们在调节药物动机和酒精动机的行为中可能发挥不同的作用。为了研究ORX神经元在乙醇（EtOH）寻找中的作用，我们通过三种不同的EtOH寻找和偏好测量方法测量了大鼠ORX神经元的Fos激活：（i）情境诱导的恢复或ABA更新; （ii）提示诱导恢复对EtOH的熄灭反应; （iii）在家笼任务中，在没有增强剂的情况下测量对EtOH（相对于水）的偏爱。我们在所有三个行为测试中的多个子区域中发现了ORX神经元的显着激活。值得注意的是，下丘脑外侧的ORX神经元激活与上下文恢复中的寻求程度以及家笼偏好测试中的偏好程度相关。此外，背丘下丘脑区和肾盂旁区的ORX神经元中的Fos激活分别与背景和笼子寻求/偏好相关。出人意料的是，尽管在恢复过程中总体激活很强，但在任何区域中，提示诱导的恢复程度与ORX神经元激活之间都没有关系。这些结果表明，ORX神经元激活与EtOH寻求/偏好之间存在很强的关系，但是在ORX场子区域中差异表达的依赖于恢复方式。

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