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首页> 外文期刊>The European Journal of Neuroscience >Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury.
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Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury.

机译：Neurotrophin-4 / 5与周围神经损伤后跑步机训练产生的轴突再生增强有关。

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摘要

The role of neurotrophin-4/5 (NT-4/5) in the enhancement of axon regeneration in peripheral nerves produced by treadmill training was studied in mice. Common fibular nerves of animals of the H strain of thy-1-YFP mice, in which a subset of axons in peripheral nerves is marked by the presence of yellow fluorescent protein, were cut and surgically repaired using nerve grafts from non-fluorescent mice. Lengths of profiles of fluorescent regenerating axons were measured using optical sections made through whole mounts of harvested nerves. Measurements from mice that had undergone 1 h of daily treadmill training at modest speed (10 m/min) were compared with those of untrained (control) mice. Modest treadmill training resulted in fluorescent axon profiles that were nearly twice as long as controls at 1, 2 and 4 week survival times. Similar enhanced regeneration was found when cut nerves of wild type mice were repaired with grafts from NT-4/5 knockout mice or grafts made acellular by repeated freezing/thawing. No enhancement was produced by treadmill training in NT-4/5 knockout mice, irrespective of the nature of the graft used to repair the cut nerve. Much as had been observed previously for the effects of brief electrical stimulation, the effects of treadmill training on axon regeneration in cut peripheral nerves are independent of changes produced in the distal segment of the cut nerve and depend on the promotion of axon regeneration by changes in NT-4/5 expression by cells in the proximal nerve segment.
机译：在小鼠中研究了神经营养蛋白4/5（NT-4 / 5）在增强跑步机训练产生的周围神经轴突再生中的作用。 thy-1-YFP小鼠H株动物的腓总神经被切开，并用非荧光小鼠的神经移植物进行了手术修复，其中周围神经的轴突亚群以黄色荧光蛋白的存在为标志。荧光再生轴突的轮廓长度是通过整个收获的神经支架的光学切片测量的。将经过每天1小时以适当速度（10 m / min）进行了跑步机训练的小鼠的测量值与未经训练（对照）的小鼠的测量值进行了比较。在跑步机上进行适度的训练后，在1、2和4周的存活时间，荧光轴突曲线的长度几乎是对照的两倍。当用来自NT-4 / 5基因敲除小鼠的移植物或通过反复冷冻/融化而脱细胞的移植物修复野生型小鼠的切割神经时，发现了类似的增强再生。在NT-4 / 5敲除小鼠中，通过跑步机训练，无论用于修复切割神经的移植物的性质如何，都不会产生增强作用。正如先前在短暂的电刺激作用中所观察到的那样，跑步机训练对切割的周围神经中轴突再生的影响与切割的神经远端段中产生的变化无关，并且取决于通过改变神经末梢来促进轴突再生。 NT-4 / 5由近端神经节中的细胞表达。

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