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首页> 外文期刊>The European Journal of Neuroscience >Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex
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Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex

机译：多巴胺转运蛋白免疫反应性纤维在人杏仁核复合物中的分布

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The nuclei of the human amygdaloid complex can be distinguished from each other on the basis of their cytoarchitecture, chemistry and connections, all of which process the information needed for the different functions (ranging from attention to memory and emotion) of the amygdala. This complex receives dopaminergic input that exerts modulatory effects over its intrinsic network and is critical for reward-related learning and fear conditioning. To determine the specific distribution of the dopaminergic input through the different nuclei and nuclear subdivisions of this structure we used stereological tools to quantify the fibers containing the dopamine transporter (used to signal the dopaminergic phenotype) in post-mortem samples from control individuals. Dopaminergic axons targeted every nucleus of the amygdaloid complex, and the density of dopamine transporter-containing axons varied considerably among its nuclear groups. The central group showed the greatest density of dopamine transporter-positive fibers, more than double the density of the basolateral group, the second most densely innervated structure. The dopamine transporter-positive innervation is very scant in the corticomedial group. The density of dopamine transporter-positive fibers did not vary among the nuclei of the basolateral group - i.e. basal, lateral and accessory basal nuclei - although there were significant density gradients among the subdivisions of these nuclei. These detailed quantitative data on dopamine transporter-positive innervation in the human amygdaloid complex can offer a useful reference in future studies aimed at analysing putative dysfunctions of this system in diseases involving brain dopamine, such as certain anxiety disorders, Parkinson's disease and schizophrenia.
机译：人类杏仁核复合物的细胞核可以根据它们的细胞结构，化学和连接来区分，所有这些都处理杏仁核的不同功能（从注意力到记忆和情感）所需的信息。该复合物接受多巴胺能输入，该输入在其内在网络上发挥调节作用，对于与奖励相关的学习和恐惧调节至关重要。为了确定通过该结构的不同核和核细分的多巴胺能输入的具体分布，我们使用了立体学工具来量化来自对照个体的验尸样品中含有多巴胺转运蛋白的纤维（用于信号多巴胺能表型）。多巴胺能轴突靶向杏仁核复合体的每个核，并且含多巴胺转运蛋白的轴突的密度在其核群之间差异很大。中心组显示出最大密度的多巴胺转运蛋白阳性纤维，是第二外侧最密集的神经支配结构基底外侧基团密度的两倍以上。在皮质类药物组中，多巴胺转运蛋白阳性的神经支配非常少。尽管在这些核的细分区域之间存在明显的密度梯度，但在基底外侧组的核（即基底，外侧和副基底核）之间多巴胺转运蛋白阳性纤维的密度没有变化。这些有关人类杏仁状体复合物中多巴胺转运蛋白阳性神经支配的详细定量数据可以为将来的研究提供有用的参考，这些研究旨在分析该系统在涉及脑多巴胺的疾病（例如某些焦虑症，帕金森氏病和精神分裂症）中的假定功能障碍。

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