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首页> 外文期刊>The European Journal of Neuroscience >Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats
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Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats

机译：生命早期应激影响青春期大鼠内侧前额叶皮层的结构和功能可塑性

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摘要

Early life experiences are crucial factors that shape brain development and function due to their ability to induce structural and functional plasticity. Among these experiences, early-life stress (ELS) is known to interfere with brain development and maturation, increasing the risk of future psychopathologies, including depression, anxiety, and personality disorders. Moreover, ELS may contribute to the emergence of these psychopathologies during adolescence. In this present study, we investigated the effects of ELS, in the form of maternal separation (MS), on the structural and functional plasticity of the medial prefrontal cortex (mPFC) and anxiety-like behavior in adolescent male rats. We found that the MS procedure resulted in disturbances in mother-pup interactions that lasted until weaning and were most strongly demonstrated by increases in nursing behavior. Moreover, MS caused atrophy of the basal dendritic tree and reduced spine density on both the apical and basal dendrites in layer II/III pyramidal neurons of the mPFC. The structural changes were accompanied by an impairment of long-term potentiation processes and increased expression of key proteins, specifically glutamate receptor 1, glutamate receptor 2, postsynaptic density protein 95, αCa2+/calmodulin-dependent protein kinase II and αCa2+/calmodulin-dependent protein kinase II phosphorylated at residue Thr305, that are engaged in long-term potentiation induction and maintenance in the mPFC. We also found that the MS animals were more anxious in the light/dark exploration test. The results of this study indicate that ELS has a significant impact on the structural and functional plasticity of the mPFC in adolescents. ELS-induced adaptive plasticity may underlie the pathomechanisms of some early-onset psychopathologies observed in adolescents.
机译：早期生活经历是诱导大脑发育和功能的关键因素，因为它们具有诱导结构和功能可塑性的能力。在这些经历中，众所周知，生命早期压力（ELS）会干扰大脑的发育和成熟，增加未来发生精神病的风险，包括抑郁症，焦虑症和人格障碍。此外，ELS可能有助于在青春期出现这些精神病学。在本研究中，我们调查了母体分离（MS）形式的ELS对青春期雄性大鼠内侧前额叶皮层（mPFC）的结构和功能可塑性以及焦虑样行为的影响。我们发现，MS程序导致了母鼠互动的干扰，这种干扰一直持续到断奶，并且护理行为的增加最明显地证明了这一点。此外，MS导致mPFC的II / III层锥体神经元的根部树突萎缩，并且根尖和基底树突的脊柱密度降低。结构变化伴随着长期增强过程的损害和关键蛋白表达的增加，特别是谷氨酸受体1，谷氨酸受体2，突触后密度蛋白95，αCa2+ /钙调蛋白依赖性蛋白激酶II和αCa2+ /钙调蛋白依赖性蛋白在残基Thr305处磷酸化的激酶II，参与mPFC的长期增强诱导和维持。我们还发现，MS动物在明/暗探索测试中更加焦虑。这项研究的结果表明，ELS对青少年mPFC的结构和功能可塑性具有重大影响。 ELS诱导的适应性可塑性可能是在青少年中观察到的一些早期发作的心理病理的病理机制的基础。

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