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首页> 外文期刊>The European Journal of Neuroscience >Social reward: Interactions with social status, social communication, aggression, and associated neural activation in the ventral tegmental area
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Social reward: Interactions with social status, social communication, aggression, and associated neural activation in the ventral tegmental area

机译：社会奖励：腹侧被盖区与社会地位，社会沟通，攻击性和相关神经激活的相互作用

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Nearly all species engage in a variety of intraspecific social interactions, and there is evidence that these interactions are rewarding. Less is known, however, about the factors that influence social reward. Using the conditioned place preference paradigm, we tested whether social interactions are rewarding for male Syrian hamsters. We also tested whether social stimuli increase neural activation in the ventral tegmental area (VTA), a component of the mesolimbic reward system, and how individual differences in social behavior and experience influence neural activation. In the present study, we found that hamsters developed a conditioned place preference for social interactions, but the effects were significantly stronger in dominant animals compared with subordinates. The number of Fos-immunoreactive cells in the VTA was significantly higher in hamsters that had engaged in a direct social encounter compared with hamsters exposed to a caged stimulus hamster or controls. Interestingly, socially experienced males had more Fos-immunoreactive cells in the VTA than socially naive males after exposure to a social stimulus. Surprisingly, the amount of Fos immunoreactivity in the VTA induced by a social stimulus was correlated with the amount of aggressive/dominance behaviors that had been observed during interactions that had occurred 2 months earlier. Our results indicate that social interactions between males are rewarding, and that social dominance increases the reward value. Social interactions stimulate the mesolimbic reward system, and social experience enhances its response to novel social stimuli and may produce long-term changes in the neural mechanisms that mediate the maintenance of dominance over long periods of time.
机译：几乎所有物种都参与各种各样的种内社会互动，并且有证据表明这些互动是有益的。然而，关于影响社会奖励的因素知之甚少。使用条件性地点偏爱范式，我们测试了社交互动是否对叙利亚男性仓鼠有好处。我们还测试了社交刺激是否增加了腹侧被盖区（VTA）（中脑边缘奖励系统的组成部分）的神经激活，以及社交行为和经历的个体差异如何影响神经激活。在本研究中，我们发现仓鼠对社交互动发展出了条件性的场所偏好，但与下属相比，优势动物对仓鼠的影响明显更大。与暴露在笼中的刺激性仓鼠或对照组中的仓鼠相比，参与直接社交活动的仓鼠中VTA中Fos免疫反应性细胞的数量明显更高。有趣的是，经历过社会刺激后，有社会经验的男性在VTA中拥有的Fos免疫反应性细胞要多于没有社会行为的男性。出人意料的是，社交刺激在VTA中引起的Fos免疫反应性与在2个月前发生的互动过程中观察到的攻击/主导行为数量相关。我们的结果表明，男性之间的社交互动是有回报的，而社会支配地位则增加了奖励价值。社交互动刺激了中脑边缘的奖励系统，社交经验增强了其对新的社交刺激的反应，并可能在介导长期维持优势的神经机制中产生长期变化。

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