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首页> 外文期刊>The European Journal of Neuroscience >Physiological markers of local sleep.
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Physiological markers of local sleep.

机译：局部睡眠的生理指标。

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Substantial evidence suggests that brain regions that have been disproportionately used during waking will require a greater intensity and/or duration of subsequent sleep. For example, rats use their whiskers in the dark and their eyes during the light, and this is manifested as a greater magnitude of electroencephalogram (EEG) slow-wave activity in the somatosensory and visual cortex during sleep in the corresponding light and dark periods respectively. The parsimonious interpretation of such findings is that sleep is distributed across local brain regions and is use-dependent. The fundamental properties of sleep can also be experimentally defined locally at the level of small neural assemblies such as cortical columns. In this view, sleep is orchestrated, but not fundamentally driven, by central mechanisms. We explore two physiological markers of local, use-dependent sleep, namely, an electrical marker apparent as a change in the size and shape of an electrical evoked response, and a metabolic marker evident as an evoked change in blood volume and oxygenation delivered to activated tissue. Both markers, applied to cortical columns, provide a means to investigate physiological mechanisms for the distributed homeostatic regulation of sleep, and may yield new insights into the consequences of sleep loss and sleep pathologies on waking brain function.
机译：大量证据表明，醒来时过度使用的大脑区域将需要更大的强度和/或随后的睡眠时间。例如，大鼠在黑暗中使用其晶须，在明亮时使用其眼睛，这表现为分别在相应的明亮和黑暗时期睡眠期间，体感和视觉皮层中较大的脑电图（EEG）慢波活动。对此类发现的简约解释是，睡眠分布在局部大脑区域，并且依赖于使用。睡眠的基本属性也可以在小型神经组件（例如皮质柱）的水平上通过实验来局部定义。从这种观点来看，睡眠是由中央机制精心策划的，但不是从根本上驱动的。我们探索了两个局部的，依赖于使用的睡眠的生理学标记，即，一个明显的电学标志物，表现为电诱发反应的大小和形状的变化，以及一个代谢性标志物，表现为诱发的血量变化和传递给激活的氧合组织。应用于皮质柱的这两种标记物提供了一种手段来研究睡眠的分布式体内稳态调节的生理机制，并且可能对睡眠丧失和睡眠病理学对唤醒脑功能的后果产生新的见解。

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