...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal.
【24h】

Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal.

机译：降钙素/食欲素有助于表达某些而非全部形式的压力和唤醒。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hypocretin/orexin has a well-established role in wakefulness and in the maintenance of arousal. Because stress is associated with arousal, it has been proposed that hypocretin is also involved in stress. However, it is not clear if this is true for all forms of stress. To clarify this issue, we compared four conditions combining high arousal with no or low stress (wakefulness and exploration) or high stress (contextual fear and restraint) in the rat. We looked at Fos expression in hypocretin neurons, hypocretin-1 levels in cerebrospinal fluid and cardiovascular and behavioural changes after pharmacological blockade with the dual hypocretin receptor antagonist, almorexant. Fos expression in hypocretin neurons was highest with wakefulness and exploration, also high with fear but not significant with restraint. Hypocretin-1 levels were consistent with this pattern, although the differences were not as marked. Hypocretin receptor blockade with almorexant reduced the pressor, tachycardic and locomotor responses of wakefulness and exploration as well as the pressor and sympathetic component of the tachycardic response of fear. In contrast, almorexant did not reduce the pressor and tachycardic responses of restraint and nor did it reduce the pressor, tachycardic and locomotor responses of another stressor, i.e. cold exposure. Thus, hypocretin is not involved in all forms of stress. Comparison of the different conditions suggests that, regardless of stress, hypocretin involvement occurs when the arousal associated with the response includes increased attention to environmental cues. When it does, hypocretin will at least contribute to the cardiovascular response. The findings are of clinical relevance to some forms of psychological stress.
机译：降钙素/食欲素在清醒和维持唤醒中具有公认的作用。由于压力与唤醒有关，因此提出了降钙素也与压力有关。但是，目前尚不清楚所有压力形式是否成立。为了澄清这个问题，我们比较了四种引起高觉醒与无压力或低压力（清醒和探索）或高压力（上下文恐惧和克制）的条件。我们用双重降钙素受体拮抗剂almorexant观察了降钙素神经元中Fos的表达，脑脊液中hypocretin-1水平以及药物和药理学阻断后心血管和行为的变化。降钙素神经元中的Fos表达在觉醒和探索时最高，在恐惧时也高，但在约束时不显着。 Hypocretin-1水平与此模式一致，尽管差异不明显。降醛素受体与阿莫沙坦的阻断减少了觉醒和探查的压力，心动过速和运动反应，以及恐惧的心动过速反应的压力和交感成分。相反，Almorexant不会降低束缚的压力和心动过速反应，也不会降低另一种应激源的压力，心动过速和运动反应，即冷暴露。因此，降钙素不参与所有形式的压力。不同条件的比较表明，不管压力如何，当与反应相关的唤醒包括对环境提示的更多关注时，就会发生促胰激素释放素的参与。如果确实如此，降钙素至少会促进心血管反应。这些发现与某些形式的心理压力具有临床意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号