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首页> 外文期刊>The European Journal of Neuroscience >Neuron synchronization in the rat gracilis nucleus facilitates sensory transmission in the somatosensory pathway.
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Neuron synchronization in the rat gracilis nucleus facilitates sensory transmission in the somatosensory pathway.

机译：大鼠纹状体核中的神经元同步促进了体感途径中的感官传递。

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摘要

We have studied the role of the temporal correlation of multiple cell discharges in the facilitation of the somatosensory information transmission from the gracilis nucleus to the primary somatosensory (SI) cortex in anesthetized rats. Pairs of gracilis neurons or gracilis-SI cortical neurons were recorded during application of 20-ms tactile stimuli in control conditions and after electrical corticofugal stimulation. Cross-correlation of neural spike trains showed significant changes in synchronization of the neuron firing provoked by the corticofugal stimulation. To quantify the time-frequency alterations in the functional association within neuron pairs we used the wavelet coherence measure. We show that electrical stimulation of the SI cortex induces a short-lasting facilitation of tactile responses of projecting gracilis neurons if their receptive fields (RFs) overlap with the RF of the stimulated cortical area (matching condition). Moreover, synchronization of discharges of gracilis neurons with a common RF is increased by activation of the corticofugal projection. Synchronization is favored by a stimulus induced synchronous oscillatory activity of projecting neurons in the range 3-10 Hz. In the matching condition synchronous discharges in the gracilis increment the number of spikes elicited in the SI cortex. Thus the efficacy of the sensory transmission from the gracilis nucleus to the SI cortex is modulated by the corticofugal projection through two complementary mechanisms: (i) by changing the responsiveness (number of elicited spikes) of individual gracilis neurons; and (ii) by a dynamic consolidation of gracilis neurons with a common RF into microcircuits generating synchronous spikes.
机译：我们已经研究了在麻醉大鼠中多个细胞放电的时间相关性在促进从体纹核到初级体感（SI）皮质的体感信息传递中的作用。在对照条件下以及在电刺激皮质兔的过程中施加20 ms的触觉刺激过程中，记录了成对的束状神经元或束状SI皮质神经元。神经峰值序列的互相关性显示，皮质皮质刺激引起的神经元放电同步发生显着变化。为了量化神经元对内功能关联中的时频变化，我们使用了小波相干度量。我们显示，如果SI皮层的电刺激场与被刺激皮层区域的RF重叠（匹配条件）重叠，则SI皮层的电刺激会诱导短剑突神经元的触觉响应的短期促进。此外，通过激活皮质肱骨突增高了神经元放电与普通RF的同步性。刺激是由3-10 Hz范围内的投射神经元的刺激诱导的同步振荡活动所促成的。在匹配条件下，笔迹中的同步放电使SI皮质中产生的尖峰数增加。因此，从皮质神经核到SI皮层的感觉传递的功效通过两个互补机制由皮质的皮质投射调节：（i）通过改变各个皮质神经元的反应性（诱发的尖峰数）; （ii）将带有普通RF的束状神经元动态整合到微电路中，从而产生同步尖峰。

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