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首页> 外文期刊>The European Journal of Neuroscience >Callosal contribution to ocular dominance in rat primary visual cortex.
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Callosal contribution to ocular dominance in rat primary visual cortex.

机译：os骨对大鼠原发性视觉皮层中眼优势的贡献。

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摘要

Ocular dominance (OD) plasticity triggered by monocular eyelid suture is a classic paradigm for studying experience-dependent changes in neural connectivity. Recently, rodents have become the most popular model for studies of OD plasticity. It is therefore important to determine how OD is determined in the rodent primary visual cortex. In particular, cortical cells receive considerable inputs from the contralateral hemisphere via callosal axons, but the role of these connections in controlling eye preference remains controversial. Here we have examined the role of callosal connections in binocularity of the visual cortex in naive young rats. We recorded cortical responses evoked by stimulation of each eye before and after acute silencing, via stereotaxic tetrodotoxin (TTX) injection, of the lateral geniculate nucleus ipsilateral to the recording site. This protocol allowed us to isolate visual responses transmitted via the corpus callosum. Cortical binocularity was assessed by visual evoked potential (VEP) and single-unit recordings. We found that acute silencing of afferent geniculocortical input produced a very significant reduction in the contralateral-to-ipsilateral (C/I) VEP ratio, and a marked shift towards the ipsilateral eye in the OD distribution of cortical cells. Analysis of absolute strength of each eye indicated a dramatic decrease in contralateral eye responses following TTX, while those of the ipsilateral eye were reduced but maintained a more evident input. We conclude that callosal connections contribute to normal OD mainly by carrying visual input from the ipsilateral eye. These data have important implications for the interpretation of OD plasticity following alterations of visual experience.
机译：单眼睑缝合引起的眼优势（OD）可塑性是研究依赖于经验的神经连通性变化的经典范例。最近，啮齿动物已经成为研究OD可塑性的最流行模型。因此，重要的是确定如何在啮齿动物的初级视觉皮层中确定OD。特别是，皮质细胞通过call轴突接受来自对侧半球的大量输入，但这些连接在控制眼球偏爱中的作用仍存在争议。在这里，我们研究了幼稚幼鼠的视皮质双目性中骨ity连接的作用。我们记录了通过静息性河豚毒素（TTX）注射，在记录部位的同侧外侧膝状核的急性沉默前后，通过刺激每只眼睛诱发的皮质反应。该协议使我们能够隔离通过call体传输的视觉响应。通过视觉诱发电位（VEP）和单单位记录评估皮质双眼性。我们发现传入的基因皮层输入的急性沉默产生了对侧对同侧（C / I）VEP比的非常显着降低，并且皮质细胞的OD分布向同侧眼明显转移。每只眼睛的绝对力量分析表明，TTX后对侧眼反应显着下降，而同侧眼的视力下降，但保持了更明显的输入。我们得出的结论是，call骨连接主要通过从同侧眼进行视觉输入来促进正常OD。这些数据对于视觉体验改变后对OD可塑性的解释具有重要意义。

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