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首页> 外文期刊>The European Journal of Neuroscience >Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats.
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Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats.

机译：在自由行进的大鼠中，足桥骨被膜盖核神经元对奖赏和运动的独立神经编码。

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摘要

Phasic firing of dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SN) is likely to be crucial for reward processing that guides learning. One of the key structures implicated in the regulation of this DA burst firing is the pedunculopontine tegmental nucleus (PPTg), which projects to both the VTA and SN. Different literatures suggest that the PPTg serves as a sensory-gating area for DA cells or it regulates voluntary movement. This study recorded PPTg single-unit activity as rats perform a spatial navigation task to examine the potential for both reward and movement contributions. PPTg cells showed significant changes in firing relative to reward acquisition, the velocity of movement across the maze and turning behaviors of the rats. Reward, but not movement, correlates were impacted by changes in context, and neither correlate type was affected by reward manipulations (e.g. changing the expected location of a reward). This suggests that the PPTg conjunctively codes both reward and behavioral information, and that the reward information is processed in a context-dependent manner. The distinct anatomical distribution of reward and movement cells emphasizes different models of synaptic control by PPTg of DA burst firing in the VTA and SN. Relevant to both VTA and SN learning systems, however, PPTg appears to serve as a sensory gating mechanism to facilitate reinforcement learning, while at the same time provides reinforcement-based guidance of ongoing goal-directed behaviors.
机译：在腹侧被盖区（VTA）和黑质（SN）中多巴胺（DA）神经元的阶段性放电对于指导学习的奖励过程可能至关重要。人脚桥骨被盖核（PPTg）牵涉到此DA爆发的调控中的关键结构之一，它同时投射到VTA和SN上。不同的文献表明，PPTg充当DA细胞的感觉门控区域或调节自愿运动。这项研究记录了PPTg单单位活动，因为大鼠执行空间导航任务来检查奖励和运动贡献的潜力。 PPTg细胞在射击过程中表现出与奖励获取，穿越迷宫的移动速度和大鼠的转向行为有关的显着变化。奖励而不是运动的关联会受到上下文变化的影响，关联类型也不会受到奖励操作的影响（例如更改奖励的预期位置）。这表明PPTg对奖励和行为信息进行了联合编码，并且奖励信息以上下文相关的方式进行处理。奖励和运动细胞的独特解剖分布强调了VTA和SN中DA爆发的PPTg突触控制的不同模型。然而，与VTA和SN学习系统都相关，PPTg似乎是一种感觉门控机制，可促进强化学习，同时又为正在进行的目标导向的行为提供基于强化的指导。

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