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首页> 外文期刊>The European Journal of Neuroscience >Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation.
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Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation.

机译：大麻素对前腹神经元对腹侧被盖区刺激的反应的影响。

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Cannabinoids activate the firing of mesoprefrontocortical dopamine neurons and release dopamine in the prefrontal cortex. This study was undertaken with the aim of clarifying the interaction between cannabinoids and mesocortical system in the prefrontal cortex. The effect of Delta9-tetrahydrocannabinol (Delta9-THC) and the synthetic CB1 agonist WIN55,212-2 (WIN) was studied by extracellular single unit recordings, in chloral hydrate anaesthetised rats, on the spontaneous activity of pyramidal neurons and on the inhibition produced on these neurons by the electrical stimulation of the ventral tegmental area (VTA). Intravenously administered Delta9-THC and WIN (1.0 and 0.5 mg/kg, respectively), increased the firing rate of pyramidal neurons projecting to the VTA. VTA stimulation produced a phasic inhibition (167 +/- 6 ms) in 79% of prefrontal cortex pyramidal neurons. Delta9-THC and WIN reverted this inhibition in 73% and 100% of the neurons tested, respectively. The subsequent administration of the selective CB1 antagonist SR141716A (1 mg/kg) readily suppressed the effects of both cannabinoids and restored the inhibitory response to VTA stimulation. Moreover, when administered alone, SR141716A prolonged the inhibition in 55.6% of the neurons tested. The results indicate that stimulation of CB1 receptors by cannabinoids results in an enhanced excitability of prefrontal cortex pyramidal neurons as indexed by the suppression of the inhibitory effect of VTA stimulation and by the increase in firing rate of antidromically identified neurons projecting to the VTA. Furthermore, our results support the view that endogenous cannabinoids exert a negative control on dopamine activity in the prefrontal cortex. This study may be relevant in helping to understand the influence of cannabinoids on cognitive processes mediated by the prefrontal cortex.
机译：大麻素激活中前额叶多巴胺神经元的放电，并在额叶前皮质释放多巴胺。进行这项研究的目的是阐明大麻素与额叶前额叶皮层中皮层系统之间的相互作用。通过细胞外单单位记录，在水合氯醛麻醉的大鼠中研究了Delta9-四氢大麻酚（Delta9-THC）和合成的CB1激动剂WIN55,212-2（WIN）对锥体神经元自发活性及其产生的抑制作用的影响。通过腹侧被盖区（VTA）的电刺激作用于这些神经元。静脉注射Delta9-THC和WIN（分别为1.0和0.5 mg / kg），可增加投射到VTA的锥体神经元的放电率。 VTA刺激在79％的前额叶皮层锥体神经元中产生了相抑制作用（167 +/- 6 ms）。 Delta9-THC和WIN分别在测试的73％和100％的神经元中恢复了这种抑制作用。随后施用选择性CB1拮抗剂SR141716A（1 mg / kg）可以轻松抑制两种大麻素的作用，并恢复对VTA刺激的抑制反应。此外，当单独给药时，SR141716A延长了对55.6％的受试神经元的抑制作用。结果表明，大麻素对CB1受体的刺激导致前额叶皮层锥体神经元的兴奋性增强，这是通过抑制VTA刺激的抑制作用以及通过投射到VTA的抗染色体识别神经元的放电速率的增加来确定的。此外，我们的结果支持以下观点：内源性大麻素对前额叶皮层中的多巴胺活性起负控制作用。这项研究可能有助于了解大麻素对额叶前额叶介导的认知过程的影响。

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