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首页> 外文期刊>The European Journal of Neuroscience >The ubiquitin-proteasome cascade is required for mammalian long-term memory formation.
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The ubiquitin-proteasome cascade is required for mammalian long-term memory formation.

机译：泛素-蛋白酶体级联是哺乳动物长期记忆形成所必需的。

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摘要

It has been recently demonstrated that ubiquitin-proteasome-mediated proteolysis is required for long-term synaptic facilitation in Aplysia. Here we show that the hippocampal blockade of this proteolytic pathway is also required for the formation of long-term memory in the rat. Bilateral infusion of lactacystin, a specific proteasome inhibitor, to the CA1 region caused full retrograde amnesia for a one-trial inhibitory avoidance learning when given 1, 4 or 7h, but not 10 h, after training. Proteasome inhibitor I produced similar effects. In addition, inhibitory avoidance training resulted in an increased ubiquitination and 26S proteasome proteolytic activity and a decrease in the levels of IkappaB, a substrate of the ubiquitin-proteasome cascade, in hippocampus 4 h after training. Together, these findings indicate that the ubiquitin-proteasome cascade is crucial for the establishment of LTM in the behaving animal.
机译：最近已经证明，在海藻中长期突触促进需要遍在蛋白-蛋白酶体介导的蛋白水解。在这里，我们表明，这种蛋白水解途径的海马阻断也是大鼠长期记忆形成所必需的。在训练后第1、4或7小时（而非10小时）给予CA1区域双侧输注一种特定的蛋白酶体抑制剂的乳腺抑制素，导致CA1区域完全逆行性健忘症。蛋白酶体抑制剂我产生了类似的效果。此外，抑制回避训练导致训练后4 h海马中泛素化和26S蛋白酶体蛋白水解活性增加，IkappaB（泛素-蛋白酶体级联反应的底物）水平降低。总之，这些发现表明泛素-蛋白酶体级联对于在行为动物中建立LTM至关重要。

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