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首页> 外文期刊>The European Journal of Neuroscience >Exposure to hypergravity during specific developmental periods differentially affects metabolism and vestibular reactions in adult C57BL /6j mice.
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Exposure to hypergravity during specific developmental periods differentially affects metabolism and vestibular reactions in adult C57BL /6j mice.

机译：在特定发育时期暴露于超重力环境下，成年C57BL / 6j小鼠的代谢和前庭反应不同。

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The development of the posturo-motor control of movement is conditioned by Earth's gravity. Missing or altered gravity during the critical periods of development delays development and induces durable changes in the vestibular, cerebellar, or muscular structures, but these are not consistently mirrored at a functional level. The differences in the time schedule of vestibular and motor development could contribute to this inconstancy. To investigate the influence of gravity on the development of vestibular and locomotor functions, we analysed the performance of adult mice subjected to hypergravity during the time covering either the vestibular or locomotor development. The mice were centrifuged at 2 g from embryonic day (E) 0 to postnatal day (P) 10 (PRE), from P10 to P30 (POST), from E0 to P30 (FULL), and from E7 to P21. Their muscular force, anxiety level, vestibular reactions, and aerobic capacity during treadmill training were then evaluated at the age of 2 and 6 months. The performance of young adults varied in relation to the period of exposure to hypergravity. The mice that acquired locomotion in hypergravity (POST and FULL) showed a lower forelimb force and delayed vestibular reactions. The mice centrifuged from conception to P10 (PRE) showed a higher aerobic capacity during treadmill training. The differences in muscular force and vestibular reactions regressed with age, but the metabolic changes persisted. These results confirmed that early exposure to hypergravity induces qualitative changes depending on the period of exposure. They validated, at a functional level, the existence of several critical periods for adaptation to gravity.
机译：运动后运动控制的发展取决于地球的重力。在发育的关键时期缺少重力或改变重力，会延迟发育并诱发前庭，小脑或肌肉结构的持久变化，但在功能水平上并不能始终如一地反映出来。前庭和运动发育时间表的差异可能会导致这种不稳定。为了调查重力对前庭和运动功能发展的影响，我们分析了在覆盖前庭或运动发展的时间内遭受超重力作用的成年小鼠的表现。从胚胎第（E）0到出生后第（P）10（PRE​​），从P10到P30（POST），从E0到P30（FULL）和从E7到P21，将小鼠离心2 g。然后在2个月和6个月大时评估他们在跑步机训练期间的肌肉力量，焦虑水平，前庭反应和有氧运动能力。年轻人的表现与超重力暴露时间有关。获得超重力运动的小鼠（POST和FULL）表现出较低的前肢力量和延迟的前庭反应。从受孕到P10（PRE​​）离心的小鼠在跑步机训练期间显示出更高的有氧运动能力。肌肉力量和前庭反应的差异随着年龄的增长而消退，但新陈代谢的变化持续存在。这些结果证实，早于超重力暴露会根据暴露时间而引起质的变化。他们在功能层面上验证了适应重力的几个关键时期的存在。

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