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首页> 外文期刊>The European Journal of Neuroscience >Interactions between superficial and deep dorsal horn spinal cord neurons in the processing of nociceptive information
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Interactions between superficial and deep dorsal horn spinal cord neurons in the processing of nociceptive information

机译：伤害性信息处理中浅表和深背角脊髓神经元之间的相互作用

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摘要

In acute rat spinal cord slices, the application of capsaicin (5μm, 90s), an agonist of transient receptor potential vanilloid 1 receptors expressed by a subset of nociceptors that project to laminae I-II of the spinal cord dorsal horn, induced an increase in the frequency of spontaneous excitatory and spontaneous inhibitory postsynaptic currents in about half of the neurons in laminae II, III-IV and V. In the presence of tetrodotoxin, which blocks action potential generation and polysynaptic transmission, capsaicin increased the frequency of miniature excitatory postsynaptic currents in only 30% of lamina II neurons and had no effect on the frequency of miniature excitatory postsynaptic currents in laminae III-V or on the frequency of miniature inhibitory postsynaptic currents in laminae II-V. When the communication between lamina V and more superficial laminae was interrupted by performing a mechanical section between laminae IV and V, capsaicin induced an increase in spontaneous excitatory postsynaptic current frequency in laminae II-IV and an increase in spontaneous inhibitory postsynaptic current frequency in lamina II that were similar to those observed in intact slices. However, in laminae III-IV of transected slices, the increase in spontaneous inhibitory postsynaptic current frequency was virtually abolished. Our results indicate that nociceptive information conveyed by transient receptor potential vanilloid 1-expressing nociceptors is transmitted from lamina II to deeper laminae essentially by an excitatory pathway and that deep laminae exert a 'feedback' control over neurons in laminae III-IV by increasing inhibitory synaptic transmission in these laminae. Moreover, we provide evidence that laminae III-IV might play an important role in the processing of nociceptive information in the dorsal horn. The dorsal horn of the spinal cord plays an important role in the integration of somatosensory information. We show that nociceptive messages are transmitted from superficial to deep laminae of the dorsal horn by an excitatory pathway and that deep laminae exert an inhibitory feedback control over more superficial laminae. In this context laminae III-IV interneurons might play an fundamental role in the integration of nociceptive and non-nociceptive sensory messages at the spinal level.
机译：在急性大鼠脊髓切片中，辣椒素（5μm，90年代）的应用是一种瞬时感受器潜在香草素1受体的激动剂，该感受器由一系列伤害感受器表达，并投射到脊髓背角的I-II层上，从而引起脊髓损伤。 II，III-IV和V层中约一半神经元中自发性兴奋性和自发性抑制性突触后电流的频率。在存在河豚毒素的情况下，辣椒素阻止动作电位的产生和多突触传递，辣椒素增加了小型兴奋性突触后电流的频率。仅在30％的层板II神经元中，并且对层板III-V的微型兴奋性突触后突触电流的频率或对板上II-V的微型抑制性突触后突触电流的频率没有影响。当通过在IV和V层之间进行机械切片来中断V层和更浅层的层之间的通讯时，辣椒素会导致II-IV层的自发性兴奋性突触后电流频率增加，而II层中的自发性抑制性突触后电流频率增加。与完整切片中观察到的相似。然而，在横切切片的层III-IV中，自发抑制的突触后电流频率的增加实际上被消除了。我们的结果表明，通过瞬时受体电位表达类香草酸1的伤害感受器传达的伤害信息主要是通过兴奋性途径从层板II传递至更深的层板，并且深层板通过增加抑制性突触对层板III-IV中的神经元施加“反馈”控制。在这些薄层中传播。此外，我们提供的证据表明，椎板III-IV可能在背角伤害感受信息的处理中起重要作用。脊髓背角在体感信息的整合中起重要作用。我们显示伤害性消息通过兴奋性途径从背角的浅层传递到深层，而深层对更多浅层施加抑制性反馈控制。在这种情况下，III-IV层间神经元可能在脊髓水平上的伤害性和非伤害性感觉信息的整合中发挥重要作用。

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