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首页> 外文期刊>The European Journal of Neuroscience >Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus
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Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus

机译：实验性癫痫影响Notch1信号传导和齿状回中的干细胞池

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Temporal lobe epilepsy (TLE) is the most frequent form of epilepsy in adults. In addition to recurrent focal seizures, patients suffer from memory loss and depression. The factors contributing to these symptoms are unknown. In recent years, adult hippocampal neurogenesis has been implicated in certain aspects of learning and memory, as well as in depression and anhedonia. Here we investigated whether the adult hippocampal stem cell niche is affected by status epilepticus in a mouse model of TLE using unilateral intrahippocampal kainic acid injection. Eight days after status epilepticus, we found a strong diminution in Notch signalling, a key pathway involved in stem cell maintenance, as assayed by hes5 reporter gene activity. In particular, hes5-GFP expression in the subgranular zone of the dentate gyrus was diminished. Furthermore, Sox2-positive cells as well as stem cell proliferation were reduced, thus pointing to a disruption of the stem cell niche in epilepsy under the present experimental conditions.
机译：颞叶癫痫（TLE）是成年人中最常见的癫痫发作形式。除局灶性癫痫发作反复发作外，患者还患有记忆力减退和抑郁。导致这些症状的因素尚不清楚。近年来，成人海马神经发生已牵涉到学习和记忆的某些方面，以及抑郁症和快感缺乏症。在这里，我们调查了单侧海马海藻酸注射液在TLE小鼠模型中成年海马干细胞的生态位是否受到癫痫持续状态的影响。癫痫持续状态八天后，我们发现hech5报道基因活性检测到，Notch信号转导是干细胞维持的关键途径，Notch信号转导明显减弱。特别地，减少了齿状回的亚颗粒区中的hes5-GFP表达。此外，Sox2阳性细胞以及干细胞增殖减少，从而表明在当前的实验条件下，癫痫中的干细胞生态位被破坏。

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